NUDT4

Nudix (nucleoside diphosphate linked moiety X)-type motif 4
PDB rendering based on 2duk.
Available structures PDB 2duk
Identifiers
Symbols	NUDT4; DIPP2; DIPP2alpha; DIPP2beta; DKFZp686I1281; KIAA0487
External IDs	OMIM: 609229 MGI: 1918457 HomoloGene: 41726 GeneCards: NUDT4 Gene
EC number	3.6.1.52
Gene Ontology Molecular function • diphosphoinositol-polyphosphate diphosphatase activity • hydrolase activity • metal ion binding Cellular component • intracellular • intracellular • cytoplasm Biological process • cyclic nucleotide metabolic process • calcium-mediated signaling • cyclic-nucleotide-mediated signaling • intracellular signal transduction • regulation of RNA export from nucleus • intracellular transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11163	71207
Ensembl	ENSG00000173598	ENSMUSG00000020029
UniProt	Q9NZJ9	Q4FJR0
RefSeq (mRNA)	NM_019094.4	NM_027722.4
RefSeq (protein)	NP_061967.3	NP_081998.3
Location (UCSC)	Chr 12: 93.77 – 93.8 Mb	Chr 10: 95.01 – 95.03 Mb
PubMed search	[1]	[2]

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.^[1][2][3]

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.^[3]

References

1. ^ Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568. 
2. ^ Caffrey JJ, Shears SB (May 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937. 
3. ^ ^{a b} "Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11163. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Seki N, Ohira M, Nagase T et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
• Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117780. 
• Fisher DI, Safrany ST, Strike P et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Fortna A, Kim Y, MacLaren E et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=449870. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.