SAP18


SAP18

Sin3A-associated protein, 18kDa, also known as SAP18, is a human gene.cite web | title = Entrez Gene: SAP18 Sin3A-associated protein, 18kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10284| accessdate = ]

PBB_Summary
section_title =
summary_text = Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.cite web | title = Entrez Gene: SAP18 Sin3A-associated protein, 18kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10284| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090
*cite journal | author=Wada M, Miyazawa H, Wang RS, "et al." |title=The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA. |journal=J. Biochem. |volume=131 |issue= 3 |pages= 307–11 |year= 2002 |pmid= 11872158 |doi=
*cite journal | author=Cheng SY, Bishop JM |title=Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5442–7 |year= 2002 |pmid= 11960000 |doi= 10.1073/pnas.082096999
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Paces-Fessy M, Boucher D, Petit E, "et al." |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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