BOK (gene)

BOK (gene)

BCL2-related ovarian killer, also known as BOK, is a human gene.cite web | title = Entrez Gene: BOK BCL2-related ovarian killer| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.cite web | title = Entrez Gene: BOK BCL2-related ovarian killer| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Hsu SY, Kaipia A, McGee E, "et al." |title=Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12401–6 |year= 1997 |pmid= 9356461 |doi=
*cite journal | author=Inohara N, Ekhterae D, Garcia I, "et al." |title=Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8705–10 |year= 1998 |pmid= 9535847 |doi=
*cite journal | author=Leo CP, Hsu SY, Chun SY, "et al." |title=Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. |journal=Endocrinology |volume=140 |issue= 12 |pages= 5469–77 |year= 1999 |pmid= 10579309 |doi=
*cite journal | author=Zhang H, Huang Q, Ke N, "et al." |title=Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27303–6 |year= 2000 |pmid= 10811653 |doi= 10.1074/jbc.M002846200
*cite journal | author=Zhang H, Holzgreve W, De Geyter C |title=Evolutionarily conserved Bok proteins in the Bcl-2 family. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 311–3 |year= 2000 |pmid= 11034351 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yakovlev AG, Di Giovanni S, Wang G, "et al." |title=BOK and NOXA are essential mediators of p53-dependent apoptosis. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28367–74 |year= 2004 |pmid= 15102863 |doi= 10.1074/jbc.M313526200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Soleymanlou N, Wu Y, Wang JX, "et al." |title=A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. |journal=Cell Death Differ. |volume=12 |issue= 5 |pages= 441–52 |year= 2005 |pmid= 15775999 |doi= 10.1038/sj.cdd.4401593
*cite journal | author=Gao S, Fu W, Dürrenberger M, "et al." |title=Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 9 |pages= 1015–24 |year= 2005 |pmid= 15868100 |doi= 10.1007/s00018-005-4543-3
*cite journal | author=Bartholomeusz G, Wu Y, Ali Seyed M, "et al." |title=Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis. |journal=Mol. Carcinog. |volume=45 |issue= 2 |pages= 73–83 |year= 2006 |pmid= 16302269 |doi= 10.1002/mc.20156
*cite journal | author=Rodriguez JM, Glozak MA, Ma Y, Cress WD |title=Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22729–35 |year= 2006 |pmid= 16772296 |doi= 10.1074/jbc.M604705200

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