ACRV1


ACRV1

Acrosomal vesicle protein 1, also known as ACRV1, is a human gene.cite web | title = Entrez Gene: ACRV1 acrosomal vesicle protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.cite web | title = Entrez Gene: ACRV1 acrosomal vesicle protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Herr JC, Klotz K, Shannon J, "et al." |title=Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes. |journal=Biol. Reprod. |volume=47 |issue= 1 |pages= 11–20 |year= 1992 |pmid= 1637938 |doi=
*cite journal | author=Wright RM, John E, Klotz K, "et al." |title=Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10. |journal=Biol. Reprod. |volume=42 |issue= 4 |pages= 693–701 |year= 1990 |pmid= 1693291 |doi=
*cite journal | author=Homyk M, Anderson DJ, Wolff H, Herr JC |title=Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10. |journal=Fertil. Steril. |volume=53 |issue= 2 |pages= 323–30 |year= 1990 |pmid= 2298314 |doi=
*cite journal | author=Freemerman AJ, Flickinger CJ, Herr JC |title=Characterization of alternatively spliced human SP-10 mRNAs. |journal=Mol. Reprod. Dev. |volume=41 |issue= 1 |pages= 100–8 |year= 1995 |pmid= 7619499 |doi= 10.1002/mrd.1080410115
*cite journal | author=Foster JA, Klotz KL, Flickinger CJ, "et al." |title=Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction. |journal=Biol. Reprod. |volume=51 |issue= 6 |pages= 1222–31 |year= 1995 |pmid= 7888499 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Golden WL, von Kap-Herr C, Kurth B, "et al." |title=Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization. |journal=Genomics |volume=18 |issue= 2 |pages= 446–9 |year= 1994 |pmid= 8288254 |doi= 10.1006/geno.1993.1496
*cite journal | author=Wright RM, Suri AK, Kornreich B, "et al." |title=Cloning and characterization of the gene coding for the human acrosomal protein SP-10. |journal=Biol. Reprod. |volume=49 |issue= 2 |pages= 316–25 |year= 1993 |pmid= 8373955 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Reddi PP, Shore AN, Acharya KK, Herr JC |title=Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10. |journal=J. Reprod. Immunol. |volume=53 |issue= 1-2 |pages= 25–36 |year= 2002 |pmid= 11730901 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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