DTL (gene)

Denticleless homolog (Drosophila)
Identifiers
Symbols	DTL; CDT2; DCAF2; L2DTL; RAMP
External IDs	OMIM: 610617 MGI: 1924093 HomoloGene: 32313 GeneCards: DTL Gene
Gene Ontology Molecular function • ubiquitin-protein ligase activity • protein binding Cellular component • nucleus • cytoplasm • centrosome • cytoskeleton • membrane • Cul4A-RING ubiquitin ligase complex • Cul4B-RING ubiquitin ligase complex • nuclear membrane Biological process • protein polyubiquitination • protein polyubiquitination • DNA replication • ubiquitin-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • protein monoubiquitination • response to DNA damage stimulus • response to UV • translesion synthesis • G2/M transition DNA damage checkpoint • regulation of cell cycle Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51514	76843
Ensembl	ENSG00000143476	ENSMUSG00000037474
UniProt	Q9NZJ0	n/a
RefSeq (mRNA)	NM_016448	NM_029766.2
RefSeq (protein)	NP_057532	NP_084042.1
Location (UCSC)	Chr 1: 212.21 – 212.28 Mb	Chr 1: 193.36 – 193.4 Mb
PubMed search	[1]	[2]

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[1][2]

Interactions

DTL (gene) has been shown to interact with P21.^[3]

References

1. ^ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750. 
2. ^ "Entrez Gene: DTL denticleless homolog (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51514. 
3. ^ Abbas, Tarek; Sivaprasad Uma, Terai Kenta, Amador Virginia, Pagano Michele, Dutta Anindya (Sep. 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. (United States) 22 (18): 2496–506. doi:10.1101/gad.1676108. ISSN 0890-9369. PMC 2546691. PMID 18794347. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2546691. 

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Banks D, Wu M, Higa LA, et al. (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.". Cell Cycle 5 (15): 1719–29. PMID 16861890. 
• Higa LA, Banks D, Wu M, et al. (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.". Cell Cycle 5 (15): 1675–80. PMID 16861906. 
• Jin J, Arias EE, Chen J, et al. (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.". Mol. Cell 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588. 
• Sansam CL, Shepard JL, Lai K, et al. (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635147. 
• Pan HW, Chou HY, Liu SH, et al. (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.". Cell Cycle 5 (22): 2676–87. PMID 17106265.