GABRA5

Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a human gene.cite web | title = Entrez Gene: GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2558| accessdate = ]

PBB_Summary
section_title =
summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.cite web | title = Entrez Gene: GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2558| accessdate = ]

ubtype selective ligands

Recent research has produced several ligands which are moderately selective for GABA_A receptors containing the α₅ subtype. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subtype have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.

Agonists

* QH-ii-066

Inverse agonists

* α5IA
* L-655,708

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Delong R |title=GABA(A) receptor alpha5 subunit as a candidate gene for autism and bipolar disorder: a proposed endophenotype with parent-of-origin and gain-of-function features,with or without oculocutaneous albinism. |journal=Autism : the international journal of research and practice |volume=11 |issue= 2 |pages= 135–47 |year= 2007 |pmid= 17353214 |doi= 10.1177/1362361307075705
*cite journal | author=Otani K, Ujike H, Tanaka Y, "et al." |title=The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder. |journal=Neurosci. Lett. |volume=381 |issue= 1-2 |pages= 108–13 |year= 2005 |pmid= 15882799 |doi= 10.1016/j.neulet.2005.02.010
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chou KC |title=Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 3 |pages= 636–42 |year= 2004 |pmid= 15033447 |doi= 10.1016/j.bbrc.2004.02.098
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ritchie RJ, Mattei MG, Lalande M |title=A large polymorphic repeat in the pericentromeric region of human chromosome 15q contains three partial gene duplications. |journal=Hum. Mol. Genet. |volume=7 |issue= 8 |pages= 1253–60 |year= 1998 |pmid= 9668167 |doi=
*cite journal | author=Kim Y, Glatt H, Xie W, "et al." |title=Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region. |journal=Genomics |volume=42 |issue= 3 |pages= 378–87 |year= 1997 |pmid= 9205108 |doi= 10.1006/geno.1997.4770
*cite journal | author=Glatt K, Glatt H, Lalande M |title=Structure and organization of GABRB3 and GABRA5. |journal=Genomics |volume=41 |issue= 1 |pages= 63–9 |year= 1997 |pmid= 9126483 |doi= 10.1006/geno.1997.4639
*cite journal | author=Knoll JH, Sinnett D, Wagstaff J, "et al." |title=FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. |journal=Hum. Mol. Genet. |volume=2 |issue= 2 |pages= 183–9 |year= 1993 |pmid= 8388764 |doi=
*cite journal | author=Russek SJ, Farb DH |title=Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. |journal=Genomics |volume=23 |issue= 3 |pages= 528–33 |year= 1995 |pmid= 7851879 |doi= 10.1006/geno.1994.1539
*cite journal | author=Glatt KA, Sinnett D, Lalande M |title=Dinucleotide repeat polymorphism at the GABAA receptor alpha 5 (GABRA5) locus at chromosome 15q11-q13. |journal=Hum. Mol. Genet. |volume=1 |issue= 5 |pages= 348 |year= 1993 |pmid= 1338907 |doi=
*cite journal | author=Wingrove P, Hadingham K, Wafford K, "et al." |title=Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit. |journal=Biochem. Soc. Trans. |volume=20 |issue= 1 |pages= 18S |year= 1992 |pmid= 1321750 |doi=

External links

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