GABRA2


GABRA2

Gamma-aminobutyric acid (GABA) A receptor, alpha 2, also known as GABRA2, is a human gene.cite web | title = Entrez Gene: GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2555| accessdate = ]

PBB_Summary
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summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.cite web | title = Entrez Gene: GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2555| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matthews AG, Hoffman EK, Zezza N, "et al." |title=The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. |journal=Journal of studies on alcohol and drugs |volume=68 |issue= 5 |pages= 625–33 |year= 2007 |pmid= 17690794 |doi=
*cite journal | author=Drgon T, D'Addario C, Uhl GR |title=Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 8 |pages= 854–60 |year= 2007 |pmid= 16894595 |doi= 10.1002/ajmg.b.30349
*cite journal | author=Agrawal A, Edenberg HJ, Foroud T, "et al." |title=Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. |journal=Behav. Genet. |volume=36 |issue= 5 |pages= 640–50 |year= 2007 |pmid= 16622805 |doi= 10.1007/s10519-006-9069-4
*cite journal | author=Dick DM, Bierut L, Hinrichs A, "et al." |title=The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. |journal=Behav. Genet. |volume=36 |issue= 4 |pages= 577–90 |year= 2006 |pmid= 16557364 |doi= 10.1007/s10519-005-9041-8
*cite journal | author=Tian H, Chen HJ, Cross TH, Edenberg HJ |title=Alternative splicing and promoter use in the human GABRA2 gene. |journal=Brain Res. Mol. Brain Res. |volume=137 |issue= 1-2 |pages= 174–83 |year= 2005 |pmid= 15950776 |doi= 10.1016/j.molbrainres.2005.03.001
*cite journal | author=Chou KC |title=Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 3 |pages= 636–42 |year= 2004 |pmid= 15033447 |doi= 10.1016/j.bbrc.2004.02.098
*cite journal | author=Edenberg HJ, Dick DM, Xuei X, "et al." |title=Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. |journal=Am. J. Hum. Genet. |volume=74 |issue= 4 |pages= 705–14 |year= 2004 |pmid= 15024690 |doi= 10.1086/383283
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bonnert TP, McKernan RM, Farrar S, "et al." |title=theta, a novel gamma-aminobutyric acid type A receptor subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9891–6 |year= 1999 |pmid= 10449790 |doi=
*cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–22 |year= 1999 |pmid= 10023064 |doi=
*cite journal | author=Hadingham KL, Wingrove P, Le Bourdelles B, "et al." |title=Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. |journal=Mol. Pharmacol. |volume=43 |issue= 6 |pages= 970–5 |year= 1993 |pmid= 8391122 |doi=
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=

External links

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