P2RX2


P2RX2
Purinergic receptor P2X, ligand-gated ion channel, 2
Identifiers
Symbols P2RX2; MGC129601; P2X2
External IDs OMIM600844 MGI2665170 HomoloGene14251 GeneCards: P2RX2 Gene
RNA expression pattern
PBB GE P2RX2 221372 s at tn.png
PBB GE P2RX2 221356 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22953 231602
Ensembl ENSG00000187848 ENSMUSG00000029503
UniProt Q9UBL9 n/a
RefSeq (mRNA) NM_012226.3 NM_153400
RefSeq (protein) NP_036358.2 NP_700449
Location (UCSC) Chr 12:
133.2 – 133.2 Mb
Chr 5:
110.77 – 110.77 Mb
PubMed search [1] [2]

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.[1][2][3]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[3]

Contents

See also

References

  1. ^ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol 56 (6): 1171–81. PMID 10570044. 
  2. ^ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature 371 (6497): 519–23. doi:10.1038/371519a0. PMID 7523952. 
  3. ^ a b "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953. 

Further reading

External links

Ionotropic glutamates ATP-gated channels B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • P2X purinoreceptor — ATP P2X receptor Identifiers Symbol P2X receptor Pfam PF00864 InterPro …   Wikipedia

  • Ligand-gated ion channel — Neurotransmitter gated ion channel transmembrane region Ligand gated ion channel Identifiers Symbol Neur chan memb Pfam …   Wikipedia


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