DDX10

DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
PDB rendering based on 2pl3.
Available structures PDB 2pl3
Identifiers
Symbols	DDX10; HRH-J8
External IDs	OMIM: 601235 MGI: 1924841 HomoloGene: 20922 GeneCards: DDX10 Gene
EC number	3.6.4.13
Gene Ontology Molecular function • nucleotide binding • RNA binding • RNA helicase activity • ATP binding • ATP-dependent helicase activity • hydrolase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1662	77591
Ensembl	ENSG00000178105	ENSMUSG00000053289
UniProt	Q13206	Q3TKX5
RefSeq (mRNA)	NM_004398	NM_029936.2
RefSeq (protein)	NP_004389	NP_084212.2
Location (UCSC)	Chr 11: 108.54 – 108.81 Mb	Chr 9: 52.91 – 53.06 Mb
PubMed search	[1]	[2]

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.^[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.^[2]

References

1. ^ Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID 8660968. 
2. ^ ^{a b} "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1662. 

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.". Cancer Cell 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• Nakao K, Nishino M, Takeuchi K, et al. (2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.". Intern. Med. 39 (5): 412–5. doi:10.2169/internalmedicine.39.412. PMID 10830185. 
• Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets.". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059. 
• Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts.". Int. J. Hematol. 69 (3): 160–4. PMID 10222653. 
• Liang WQ, Clark JA, Fournier MJ (1997). "The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.". Mol. Cell. Biol. 17 (7): 4124–32. PMC 232266. PMID 9199348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232266. 
• Arai Y, Hosoda F, Kobayashi H, et al. (1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.". Blood 89 (11): 3936–44. PMID 9166830.