Adaptor-related protein complex 2, sigma 1 subunit, also known as AP2S1, is a human gene.cite web | title = Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175| accessdate = ]

section_title =
summary_text = One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.cite web | title = Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175| accessdate = ]


Further reading

citations =
*cite journal | author=Pearse BM, Smith CJ, Owen DJ |title=Clathrin coat construction in endocytosis. |journal=Curr. Opin. Struct. Biol. |volume=10 |issue= 2 |pages= 220–8 |year= 2000 |pmid= 10753805 |doi=
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Byland R, Vance PJ, Hoxie JA, Marsh M |title=A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. |journal=Mol. Biol. Cell |volume=18 |issue= 2 |pages= 414–25 |year= 2007 |pmid= 17108326 |doi= 10.1091/mbc.E06-06-0535
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Batonick M, Favre M, Boge M, "et al." |title=Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. |journal=Virology |volume=342 |issue= 2 |pages= 190–200 |year= 2006 |pmid= 16139856 |doi= 10.1016/j.virol.2005.08.001
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vendeville A, Rayne F, Bonhoure A, "et al." |title=HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2347–60 |year= 2005 |pmid= 15020715 |doi= 10.1091/mbc.E03-12-0921
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Collins BM, McCoy AJ, Kent HM, "et al." |title=Molecular architecture and functional model of the endocytic AP2 complex. |journal=Cell |volume=109 |issue= 4 |pages= 523–35 |year= 2002 |pmid= 12086608 |doi=
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Holzmann K, Pöltl A, Sauermann G |title=A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17. |journal=Gene |volume=220 |issue= 1-2 |pages= 39–44 |year= 1998 |pmid= 9767099 |doi=
*cite journal | author=Winterpacht A, Endele S, Enklaar T, "et al." |title=Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3. |journal=Cytogenet. Cell Genet. |volume=75 |issue= 2-3 |pages= 132–5 |year= 1997 |pmid= 9040778 |doi=
*cite journal | author=Page LJ, Robinson MS |title=Targeting signals and subunit interactions in coated vesicle adaptor complexes. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 619–30 |year= 1995 |pmid= 7593184 |doi=
*cite journal | author=Kirchhausen T, Nathanson KL, Matsui W, "et al." |title=Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 8 |pages= 2612–6 |year= 1989 |pmid= 2495531 |doi=
*cite journal | author=Kirchhausen T, Davis AC, Frucht S, "et al." |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153–7 |year= 1991 |pmid= 2040623 |doi=

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