GRHPR


GRHPR

Glyoxylate reductase/hydroxypyruvate reductase, also known as GRHPR, is a human gene.cite web | title = Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9380| accessdate = ]

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.cite web | title = Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9380| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takayama T, Nagata M, Ozono S, "et al." |title=A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 8 |pages= 2371–4 |year= 2007 |pmid= 17510093 |doi= 10.1093/ndt/gfm271
*cite journal | author=Booth MP, Conners R, Rumsby G, Brady RL |title=Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. |journal=J. Mol. Biol. |volume=360 |issue= 1 |pages= 178–89 |year= 2006 |pmid= 16756993 |doi= 10.1016/j.jmb.2006.05.018
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Webster KE, Ferree PM, Holmes RP, Cramer SD |title=Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2). |journal=Hum. Genet. |volume=107 |issue= 2 |pages= 176–85 |year= 2000 |pmid= 11030416 |doi=
*cite journal | author=Huang T, Yang W, Pereira AC, "et al." |title=Cloning and characterization of a putative human d-2-hydroxyacid dehydrogenase in chromosome 9q. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 298–301 |year= 2000 |pmid= 10679197 |doi= 10.1006/bbrc.2000.2122
*cite journal | author=Rumsby G, Cregeen DP |title=Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 3 |pages= 383–8 |year= 1999 |pmid= 10524214 |doi=
*cite journal | author=Cramer SD, Ferree PM, Lin K, "et al." |title=The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. |journal=Hum. Mol. Genet. |volume=8 |issue= 11 |pages= 2063–9 |year= 1999 |pmid= 10484776 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Hyperoxalurie — Klassifikation nach ICD 10 E74.8 Sonstige näher bezeichnete Störungen des Kohlenhydratstoffwechsels Oxalurie …   Deutsch Wikipedia

  • Chromosome 9 (human) — Chromosome 9 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome, as they normally do with all chromosomes. Chromosome 9 spans about 145 million base pairs of nucleic acids (the building blocks of… …   Wikipedia

  • D-Glyceric acidemia — Classification and external resources OMIM 220120 D Glyceric Acidemia (a.k.a. D Glyceric Aciduria) is an inherited disease, in the category of inborn errors of metabolism. It is caused by a mutation in the gene GLYCTK, which encodes the for the… …   Wikipedia

  • Hyperoxaluria — Classification and external resources Oxalate ICD 10 E …   Wikipedia

  • Primary hyperoxaluria — Classification and external resources DiseasesDB 6280 Primary hyperoxaluria results in increased excretion of oxalate, with oxalate stones being common. The oxalalate in these common conditions is derived from dietary sources or is secondary to… …   Wikipedia

  • Cromosoma 9 (humano) — Saltar a navegación, búsqueda El cromosoma 9 es uno de los 23 pares de cromosomas de los seres humanos. Posee en torno a 145 millones de pares de bases (el material constituyente del ADN) y representa entre el 4% y el 4.5% del ADN total de la… …   Wikipedia Español

  • 9-я хромосома человека — Идиограмма 9 й хромосомы человека 9 я хромосома человека  одна из хромосом человеческого генома. Содержит около 145 миллионов пар оснований, составляя от 4 % до 4,5 % всего клеточного материала ДНК. По разным оц …   Википедия

  • type II — primary hyperoxaluria, milder than type I, caused by mutation in the GRHPR gene (locus: 9cen), resulting in a defect in an enzyme complex involved in the metabolism of hydroxypyruvate to D glycerate …   Medical dictionary


We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.