CENPH


CENPH

Centromere protein H, also known as CENPH, is a human gene.cite web | title = Entrez Gene: CENPH centromere protein H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64946| accessdate = ]

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summary_text = Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.cite web | title = Entrez Gene: CENPH centromere protein H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64946| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sugata N, Li S, Earnshaw WC, "et al." |title=Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. |journal=Hum. Mol. Genet. |volume=9 |issue= 19 |pages= 2919–26 |year= 2001 |pmid= 11092768 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Saffery R, Sumer H, Hassan S, "et al." |title=Transcription within a functional human centromere. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 509–16 |year= 2003 |pmid= 14536089 |doi=
*cite journal | author=Obuse C, Yang H, Nozaki N, "et al." |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Obuse C, Iwasaki O, Kiyomitsu T, "et al." |title=A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1135–41 |year= 2004 |pmid= 15502821 |doi= 10.1038/ncb1187
*cite journal | author=Mikami Y, Hori T, Kimura H, Fukagawa T |title=The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. |journal=Mol. Cell. Biol. |volume=25 |issue= 5 |pages= 1958–70 |year= 2005 |pmid= 15713649 |doi= 10.1128/MCB.25.5.1958-1970.2005
*cite journal | author=Tomonaga T, Matsushita K, Ishibashi M, "et al." |title=Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. |journal=Cancer Res. |volume=65 |issue= 11 |pages= 4683–9 |year= 2005 |pmid= 15930286 |doi= 10.1158/0008-5472.CAN-04-3613
*cite journal | author=Foltz DR, Jansen LE, Black BE, "et al." |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458–69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397
*cite journal | author=Okada M, Cheeseman IM, Hori T, "et al." |title=The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 446–57 |year= 2006 |pmid= 16622420 |doi= 10.1038/ncb1396
*cite journal | author=Izuta H, Ikeno M, Suzuki N, "et al." |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x
*cite journal | author=Orthaus S, Ohndorf S, Diekmann S |title=RNAi knockdown of human kinetochore protein CENP-H. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 36–46 |year= 2006 |pmid= 16875666 |doi= 10.1016/j.bbrc.2006.06.187
*cite journal | author=Liao WT, Song LB, Zhang HZ, "et al." |title=Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. |journal=Clin. Cancer Res. |volume=13 |issue= 2 Pt 1 |pages= 508–14 |year= 2007 |pmid= 17255272 |doi= 10.1158/1078-0432.CCR-06-1512
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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