Peptidyl arginine deiminase, type III
Symbols PADI3; MGC126307; MGC126308; PAD3; PDI3
External IDs OMIM606755 MGI1338891 HomoloGene7882 GeneCards: PADI3 Gene
EC number
RNA expression pattern
PBB GE PADI3 220779 at tn.png
More reference expression data
Species Human Mouse
Entrez 51702 18601
Ensembl ENSG00000142619 ENSMUSG00000025328
UniProt Q9ULW8 Q5DTJ8
RefSeq (mRNA) NM_016233 NM_011060.4
RefSeq (protein) NP_057317 NP_035190.3
Location (UCSC) Chr 1:
17.58 – 17.61 Mb
Chr 4:
140.34 – 140.37 Mb
PubMed search [1] [2]

Peptidyl arginine deiminase, type III, also known as PADI3, is a protein which in humans is encoded by the PADI3 gene.[1][2]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.[1]

See also


  1. ^ a b "Entrez Gene: PADI3 peptidyl arginine deiminase, type III". 
  2. ^ Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H (November 2000). "Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin". The Journal of investigative dermatology 115 (5): 813–23. doi:10.1046/j.1523-1747.2000.00131.x. PMID 11069618. 

Further reading

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