- TRDMT1
TRNA aspartic acid methyltransferase 1, also known as TRDMT1, is a human
gene .cite web | title = Entrez Gene: TRDMT1 tRNA aspartic acid methyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1787| accessdate = ]PBB_Summary
section_title =
summary_text = CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: TRDMT1 tRNA aspartic acid methyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1787| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Yoder JA, Bestor TH |title=A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. |journal=Hum. Mol. Genet. |volume=7 |issue= 2 |pages= 279–84 |year= 1998 |pmid= 9425235 |doi=
*cite journal | author=Okano M, Xie S, Li E |title=Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. |journal=Nucleic Acids Res. |volume=26 |issue= 11 |pages= 2536–40 |year= 1998 |pmid= 9592134 |doi=
*cite journal | author=Van den Wyngaert I, Sprengel J, Kass SU, Luyten WH |title=Cloning and analysis of a novel human putative DNA methyltransferase. |journal=FEBS Lett. |volume=426 |issue= 2 |pages= 283–9 |year= 1998 |pmid= 9599025 |doi=
*cite journal | author=Vilain A, Apiou F, Dutrillaux B, Malfoy B |title=Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 1-2 |pages= 120 |year= 1998 |pmid= 9763678 |doi=
*cite journal | author=Dong A, Yoder JA, Zhang X, "et al." |title=Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. |journal=Nucleic Acids Res. |volume=29 |issue= 2 |pages= 439–48 |year= 2001 |pmid= 11139614 |doi=
*cite journal | author=Franchina M, Hooper J, Kay PH |title=Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 11 |pages= 1104–15 |year= 2001 |pmid= 11551826 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hermann A, Schmitt S, Jeltsch A |title=The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 31717–21 |year= 2003 |pmid= 12794065 |doi= 10.1074/jbc.M305448200
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Xiong Y, Dowdy SC, Xue A, "et al." |title=Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. |journal=Gynecol. Oncol. |volume=96 |issue= 3 |pages= 601–9 |year= 2005 |pmid= 15721400 |doi= 10.1016/j.ygyno.2004.11.047
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Pang ST, Weng WH, Flores-Morales A, "et al." |title=Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer. |journal=Prostate |volume=66 |issue= 2 |pages= 157–72 |year= 2006 |pmid= 16173030 |doi= 10.1002/pros.20328
*cite journal | author=Goll MG, Kirpekar F, Maggert KA, "et al." |title=Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. |journal=Science |volume=311 |issue= 5759 |pages= 395–8 |year= 2006 |pmid= 16424344 |doi= 10.1126/science.1120976PBB_Controls
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