- OR2K2
-
Olfactory receptor, family 2, subfamily K, member 2 Identifiers Symbols OR2K2; HSHTPCRH06; HTPCRH06; MGC133152; OR2AN1P; OR2AR1P External IDs MGI: 3030101 HomoloGene: 17436 GeneCards: OR2K2 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to membraneBiological process • sensory perception of smell
• response to stimulusSources: Amigo / QuickGO RNA expression pattern 
More reference expression data Orthologs Species Human Mouse Entrez 26248 258922 Ensembl ENSG00000171133 ENSMUSG00000043385 UniProt Q8NGT1 n/a RefSeq (mRNA) NM_205859 NM_146920.2 RefSeq (protein) NP_995581 NP_667131.2 Location (UCSC) Chr 9:
114.09 – 114.09 MbChr 4:
58.8 – 58.8 MbPubMed search [1] [2] Olfactory receptor 2K2 is a protein that in humans is encoded by the OR2K2 gene.[1][2][3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
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See also
References
- ^ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
- ^ Aloni R, Olender T, Lancet D (Jan 2007). "Ancient genomic architecture for mammalian olfactory receptor clusters". Genome Biol 7 (10): R88. doi:10.1186/gb-2006-7-10-r88. PMC 1794568. PMID 17010214. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1794568.
- ^ a b "Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26248.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class II
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- Transmembrane receptor stubs
- G protein coupled receptors
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