CAPG


CAPG

Capping protein (actin filament), gelsolin-like, also known as CAPG, is a human gene.cite web | title = Entrez Gene: CAPG capping protein (actin filament), gelsolin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=822| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.cite web | title = Entrez Gene: CAPG capping protein (actin filament), gelsolin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=822| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dabiri GA, Young CL, Rosenbloom J, Southwick FS |title=Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. |journal=J. Biol. Chem. |volume=267 |issue= 23 |pages= 16545–52 |year= 1992 |pmid= 1322908 |doi=
*cite journal | author=Southwick FS |title=Gain-of-function mutations conferring actin-severing activity to human macrophage cap G. |journal=J. Biol. Chem. |volume=270 |issue= 1 |pages= 45–8 |year= 1995 |pmid= 7814409 |doi=
*cite journal | author=Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS |title=The human actin-regulatory protein cap G: gene structure and chromosome location. |journal=Genomics |volume=23 |issue= 3 |pages= 560–5 |year= 1995 |pmid= 7851883 |doi= 10.1006/geno.1994.1543
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hirano T, Kobayashi R, Hirano M |title=Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. |journal=Cell |volume=89 |issue= 4 |pages= 511–21 |year= 1997 |pmid= 9160743 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Cabello OA, Eliseeva E, He WG, "et al." |title=Cell cycle-dependent expression and nucleolar localization of hCAP-H. |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3527–37 |year= 2002 |pmid= 11694586 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Van Impe K, De Corte V, Eichinger L, "et al." |title=The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17945–52 |year= 2003 |pmid= 12637565 |doi= 10.1074/jbc.M209946200
*cite journal | author=Pellieux C, Desgeorges A, Pigeon CH, "et al." |title=Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29136–44 |year= 2003 |pmid= 12754261 |doi= 10.1074/jbc.M300598200
*cite journal | author=De Corte V, Van Impe K, Bruyneel E, "et al." |title=Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. |journal=J. Cell. Sci. |volume=117 |issue= Pt 22 |pages= 5283–92 |year= 2005 |pmid= 15454578 |doi= 10.1242/jcs.01410
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Watari A, Takaki K, Higashiyama S, "et al." |title=Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG. |journal=Oncogene |volume=25 |issue= 56 |pages= 7373–80 |year= 2007 |pmid= 16767159 |doi= 10.1038/sj.onc.1209732
*cite journal | author=Chi A, Valencia JC, Hu ZZ, "et al." |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j

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