Atonal homolog 1 (Drosophila), also known as ATOH1, is a human gene.cite web | title = Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)| url =| accessdate = ]

section_title =
summary_text = This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.cite web | title = Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)| url =| accessdate = ] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the "Drosophila melanogaster" gene "atonal". ATOH1 is considered part of the Notch pathway.


Further reading

citations =
*cite journal | author=Ben-Arie N, McCall AE, Berkman S, "et al." |title=Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1207–16 |year= 1997 |pmid= 8872459 |doi=
*cite journal | author=Helms AW, Johnson JE |title=Progenitors of dorsal commissural interneurons are defined by MATH1 expression. |journal=Development |volume=125 |issue= 5 |pages= 919–28 |year= 1998 |pmid= 9449674 |doi=
*cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200
*cite journal | author=Brown NL, Dagenais SL, Chen CM, Glaser T |title=Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. |journal=Mamm. Genome |volume=13 |issue= 2 |pages= 95–101 |year= 2002 |pmid= 11889557 |doi= 10.1007/s00335-001-2101-3
*cite journal | author=Leonard JH, Cook AL, Van Gele M, "et al." |title=Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. |journal=Int. J. Cancer |volume=101 |issue= 2 |pages= 103–10 |year= 2002 |pmid= 12209986 |doi= 10.1002/ijc.10554
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gazit R, Krizhanovsky V, Ben-Arie N |title=Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. |journal=Development |volume=131 |issue= 4 |pages= 903–13 |year= 2004 |pmid= 14757642 |doi= 10.1242/dev.00982
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Leow CC, Polakis P, Gao WQ |title=A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. |journal=Ann. N. Y. Acad. Sci. |volume=1059 |issue= |pages= 174–83 |year= 2006 |pmid= 16382053 |doi= 10.1196/annals.1339.048
*cite journal | author=Sekine A, Akiyama Y, Yanagihara K, Yuasa Y |title=Hath1 up-regulates gastric mucin gene expression in gastric cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 4 |pages= 1166–71 |year= 2006 |pmid= 16647036 |doi= 10.1016/j.bbrc.2006.03.238
*cite journal | author=Mutoh H, Sakamoto H, Hayakawa H, "et al." |title=The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. |journal=Differentiation |volume=74 |issue= 6 |pages= 313–21 |year= 2006 |pmid= 16831200 |doi= 10.1111/j.1432-0436.2006.00074.x
*cite journal | author=Park ET, Oh HK, Gum JR, "et al." |title=HATH1 expression in mucinous cancers of the colorectum and related lesions. |journal=Clin. Cancer Res. |volume=12 |issue= 18 |pages= 5403–10 |year= 2006 |pmid= 17000673 |doi= 10.1158/1078-0432.CCR-06-0573
*cite journal | author=Tsuchiya K, Nakamura T, Okamoto R, "et al." |title=Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. |journal=Gastroenterology |volume=132 |issue= 1 |pages= 208–20 |year= 2007 |pmid= 17241872 |doi= 10.1053/j.gastro.2006.10.031
*cite journal | author=Du X, Jensen P, Goldowitz D, Hamre KM |title=Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice. |journal=Dev. Biol. |volume=305 |issue= 2 |pages= 430–8 |year= 2007 |pmid= 17397818 |doi= 10.1016/j.ydbio.2007.02.028
*cite journal | author=Westerman BA, Breuer RH, Poutsma A, "et al." |title=Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. |journal=Int. J. Biol. Markers |volume=22 |issue= 2 |pages= 114–23 |year= 2007 |pmid= 17549667 |doi=
*cite journal | author=Scheffer D, Sage C, Corey DP, Pingault V |title=Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4651–6 |year= 2007 |pmid= 17826772 |doi= 10.1016/j.febslet.2007.08.059
*cite journal | author=Shroyer NF, Helmrath MA, Wang VY, Antalffy B, Henning SJ, Zoghbi HY |title=Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. |journal=Gastroenterology |volume=132 |issue= 7 |pages= 2478-88 |year= 2007 |pmid= 17570220 |doi= 10.1053/j.gastro.2007.03.047

External links


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