Hyaluronan synthase 3, also known as HAS3, is a human gene.cite web | title = Entrez Gene: HAS3 hyaluronan synthase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3038| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HAS3 hyaluronan synthase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3038| accessdate = ]


Further reading

citations =
*cite journal | author=Spicer AP, Olson JS, McDonald JA |title=Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 8957–61 |year= 1997 |pmid= 9083017 |doi=
*cite journal | author=Spicer AP, Seldin MF, Olsen AS, "et al." |title=Chromosomal localization of the human and mouse hyaluronan synthase genes. |journal=Genomics |volume=41 |issue= 3 |pages= 493–7 |year= 1997 |pmid= 9169154 |doi= 10.1006/geno.1997.4696
*cite journal | author=Jacobson A, Brinck J, Briskin MJ, "et al." |title=Expression of human hyaluronan synthases in response to external stimuli. |journal=Biochem. J. |volume=348 Pt 1 |issue= |pages= 29–35 |year= 2000 |pmid= 10794710 |doi=
*cite journal | author=Simpson MA, Reiland J, Burger SR, "et al." |title=Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17949–57 |year= 2001 |pmid= 11278609 |doi= 10.1074/jbc.M010064200
*cite journal | author=Kuroda K, Utani A, Hamasaki Y, Shinkai H |title=Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts. |journal=J. Dermatol. Sci. |volume=26 |issue= 2 |pages= 156–60 |year= 2001 |pmid= 11378333 |doi=
*cite journal | author=Liu N, Gao F, Han Z, "et al." |title=Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. |journal=Cancer Res. |volume=61 |issue= 13 |pages= 5207–14 |year= 2001 |pmid= 11431361 |doi=
*cite journal | author=Simpson MA, Wilson CM, Furcht LT, "et al." |title=Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10050–7 |year= 2002 |pmid= 11790779 |doi= 10.1074/jbc.M110069200
*cite journal | author=Sayo T, Sugiyama Y, Takahashi Y, "et al." |title=Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. |journal=J. Invest. Dermatol. |volume=118 |issue= 1 |pages= 43–8 |year= 2002 |pmid= 11851874 |doi= 10.1046/j.0022-202x.2001.01613.x
*cite journal | author=Chagnon P, Michaud J, Mitchell G, "et al." |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443–9 |year= 2003 |pmid= 12417987 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bullard KM, Kim HR, Wheeler MA, "et al." |title=Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. |journal=Int. J. Cancer |volume=107 |issue= 5 |pages= 739–46 |year= 2004 |pmid= 14566823 |doi= 10.1002/ijc.11475
*cite journal | author=Suzuki K, Yamamoto T, Usui T, "et al." |title=Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. |journal=Jpn. J. Ophthalmol. |volume=47 |issue= 6 |pages= 557–64 |year= 2004 |pmid= 14636845 |doi=
*cite journal | author=Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM |title=Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells. |journal=Biochim. Biophys. Acta |volume=1760 |issue= 6 |pages= 890–5 |year= 2006 |pmid= 16564133 |doi= 10.1016/j.bbagen.2006.02.002
*cite journal | author=Campo GM, Avenoso A, Campo S, "et al." |title=TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate. |journal=Mol. Cell. Biochem. |volume=292 |issue= 1-2 |pages= 169–78 |year= 2007 |pmid= 16786194 |doi= 10.1007/s11010-006-9230-7

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