ADCY8

Adenylate cyclase 8 (brain), also known as ADCY8, is a human gene.cite web | title = Entrez Gene: ADCY8 adenylate cyclase 8 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114| accessdate = ]

PBB_Summary
section_title =
summary_text = Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclasecite web | title = Entrez Gene: ADCY8 adenylate cyclase 8 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stengel D, Parma J, Gannagé MH, "et al." |title=Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. |journal=Hum. Genet. |volume=90 |issue= 1-2 |pages= 126–30 |year= 1992 |pmid= 1427768 |doi=
*cite journal | author=Parma J, Stengel D, Gannage MH, "et al." |title=Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 1 |pages= 455–62 |year= 1991 |pmid= 1715695 |doi=
*cite journal | author=Defer N, Marinx O, Stengel D, "et al." |title=Molecular cloning of the human type VIII adenylyl cyclase. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 109–13 |year= 1994 |pmid= 8076676 |doi=
*cite journal | author=Cali JJ, Zwaagstra JC, Mons N, "et al." |title=Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12190–5 |year= 1994 |pmid= 8163524 |doi=
*cite journal | author=Gu C, Cooper DM |title=Calmodulin-binding sites on adenylyl cyclase type VIII. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 8012–21 |year= 1999 |pmid= 10075700 |doi=
*cite journal | author=Barcova M, Speth C, Kacani L, "et al." |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=
*cite journal | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=
*cite journal | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=
*cite journal | author=Parkinson NA, Bolsover SR |title=A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. |journal=Brain Res. Mol. Brain Res. |volume=91 |issue= 1-2 |pages= 43–9 |year= 2001 |pmid= 11457491 |doi=
*cite journal | author=Speth C, Schabetsberger T, Mohsenipour I, "et al." |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79–110 |year= 2003 |pmid= 12503609 |doi=
*cite journal | author=Georget M, Mateo P, Vandecasteele G, "et al." |title=Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8). |journal=FASEB J. |volume=17 |issue= 11 |pages= 1380–91 |year= 2003 |pmid= 12890691 |doi= 10.1096/fj.02-0784com
*cite journal | author=Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM |title=A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. |journal=Mol. Pharmacol. |volume=69 |issue= 2 |pages= 608–17 |year= 2006 |pmid= 16258073 |doi= 10.1124/mol.105.018275
*cite journal | author=Simpson RE, Ciruela A, Cooper DM |title=The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17379–89 |year= 2006 |pmid= 16613843 |doi= 10.1074/jbc.M510992200
*cite journal | author=Nlend MC, Schmid A, Sutto Z, "et al." |title=Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. |journal=FEBS Lett. |volume=581 |issue= 17 |pages= 3241–6 |year= 2007 |pmid= 17586501 |doi= 10.1016/j.febslet.2007.06.015

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