ABCA7


ABCA7

ATP-binding cassette, sub-family A (ABC1), member 7, also known as ABCA7, is a human gene.cite web | title = Entrez Gene: ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10347| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. Alternative splicing of this gene results in two transcript variants.cite web | title = Entrez Gene: ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10347| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kaminski WE, Orsó E, Diederich W, "et al." |title=Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 532–8 |year= 2000 |pmid= 10873640 |doi= 10.1006/bbrc.2000.2954
*cite journal | author=Niwa M, Maruyama H, Fujimoto T, "et al." |title=Affinity selection of cDNA libraries by lambda phage surface display. |journal=Gene |volume=256 |issue= 1-2 |pages= 229–36 |year= 2001 |pmid= 11054552 |doi=
*cite journal | author=Kaminski WE, Piehler A, Schmitz G |title=Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 782–9 |year= 2001 |pmid= 11095984 |doi= 10.1006/bbrc.2000.3880
*cite journal | author=Tanaka AR, Ikeda Y, Abe-Dohmae S, "et al." |title=Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1019–25 |year= 2001 |pmid= 11355874 |doi= 10.1006/bbrc.2001.4891
*cite journal | author=Broccardo C, Osorio J, Luciani MF, "et al." |title=Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 264–70 |year= 2001 |pmid= 11435699 |doi=
*cite journal | author=Iida A, Saito S, Sekine A, "et al." |title=Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. |journal=J. Hum. Genet. |volume=47 |issue= 6 |pages= 285–310 |year= 2002 |pmid= 12111378 |doi= 10.1007/s100380200041
*cite journal | author=Wang N, Lan D, Gerbod-Giannone M, "et al." |title=ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42906–12 |year= 2003 |pmid= 12917409 |doi= 10.1074/jbc.M307831200
*cite journal | author=Kielar D, Kaminski WE, Liebisch G, "et al." |title=Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. |journal=J. Invest. Dermatol. |volume=121 |issue= 3 |pages= 465–74 |year= 2003 |pmid= 12925201 |doi= 10.1046/j.1523-1747.2003.12404.x
*cite journal | author=Abe-Dohmae S, Ikeda Y, Matsuo M, "et al." |title=Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 604–11 |year= 2004 |pmid= 14570867 |doi= 10.1074/jbc.M309888200
*cite journal | author=Ikeda Y, Abe-Dohmae S, Munehira Y, "et al." |title=Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 2 |pages= 313–8 |year= 2004 |pmid= 14592415 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Hayashi M, Abe-Dohmae S, Okazaki M, "et al." |title=Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. |journal=J. Lipid Res. |volume=46 |issue= 8 |pages= 1703–11 |year= 2005 |pmid= 15930518 |doi= 10.1194/jlr.M500092-JLR200
*cite journal | author=Jehle AW, Gardai SJ, Li S, "et al." |title=ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. |journal=J. Cell Biol. |volume=174 |issue= 4 |pages= 547–56 |year= 2006 |pmid= 16908670 |doi= 10.1083/jcb.200601030

External links

*

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