UBE4B


UBE4B

Ubiquitination factor E4B (UFD2 homolog, yeast), also known as UBE4B, is a human gene.cite web | title = Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10277| accessdate = ] PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.cite web | title = Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10277| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Onyango P, Lubyova B, Gardellin P, "et al." |title=Molecular cloning and expression analysis of five novel genes in chromosome 1p36 |journal=Genomics |volume=50 |issue= 2 |pages= 187–98 |year= 1998 |pmid= 9653645 |doi= 10.1006/geno.1997.5186
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Koegl M, Hoppe T, Schlenker S, "et al." |title=A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly |journal=Cell |volume=96 |issue= 5 |pages= 635–44 |year= 1999 |pmid= 10089879 |doi=
*cite journal | author=Ohira M, Kageyama H, Mihara M, "et al." |title=Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line |journal=Oncogene |volume=19 |issue= 37 |pages= 4302–7 |year= 2000 |pmid= 10980605 |doi= 10.1038/sj.onc.1203786
*cite journal | author=Mahoney JA, Odin JA, White SM, "et al." |title=The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 587–95 |year= 2002 |pmid= 11802788 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kaneko C, Hatakeyama S, Matsumoto M, "et al." |title=Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 297–304 |year= 2003 |pmid= 12504083 |doi=
*cite journal | author=Krona C, Ejeskär K, Abel F, "et al." |title=Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2 |journal=Oncogene |volume=22 |issue= 15 |pages= 2343–51 |year= 2003 |pmid= 12700669 |doi= 10.1038/sj.onc.1206324
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Okumura F, Hatakeyama S, Matsumoto M, "et al." |title=Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53533–43 |year= 2005 |pmid= 15466860 |doi= 10.1074/jbc.M402916200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Spinette S, Mahoney JA, Rosen A |title=The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 4 |pages= 1103–12 |year= 2006 |pmid= 16870146 |doi= 10.1016/j.bbrc.2006.06.194
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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