Gem (nuclear organelle) associated protein 4, also known as GEMIN4, is a human gene.cite web | title = Entrez Gene: GEMIN4 gem (nuclear organelle) associated protein 4| url =| accessdate = ]

section_title =
summary_text = The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.cite web | title = Entrez Gene: GEMIN4 gem (nuclear organelle) associated protein 4| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Charroux B, Pellizzoni L, Perkinson RA, "et al." |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177–86 |year= 2000 |pmid= 10725331 |doi=
*cite journal | author=Meister G, Bühler D, Laggerbauer B, "et al." |title=Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 13 |pages= 1977–86 |year= 2000 |pmid= 10942426 |doi=
*cite journal | author=Pellizzoni L, Charroux B, Rappsilber J, "et al." |title=A functional interaction between the survival motor neuron complex and RNA polymerase II. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 75–85 |year= 2001 |pmid= 11149922 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Park JW, Voss PG, Grabski S, "et al." |title=Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. |journal=Nucleic Acids Res. |volume=29 |issue= 17 |pages= 3595–602 |year= 2001 |pmid= 11522829 |doi=
*cite journal | author=Qin WX, Wan F, Sun FY, "et al." |title=Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma. |journal=Cell Res. |volume=11 |issue= 3 |pages= 209–16 |year= 2002 |pmid= 11642406 |doi= 10.1038/
*cite journal | author=Friesen WJ, Paushkin S, Wyce A, "et al." |title=The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. |journal=Mol. Cell. Biol. |volume=21 |issue= 24 |pages= 8289–300 |year= 2001 |pmid= 11713266 |doi= 10.1128/MCB.21.24.8289-8300.2001
*cite journal | author=Gubitz AK, Mourelatos Z, Abel L, "et al." |title=Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5631–6 |year= 2002 |pmid= 11714716 |doi= 10.1074/jbc.M109448200
*cite journal | author=Pellizzoni L, Baccon J, Rappsilber J, "et al." |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540–5 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200
*cite journal | author=Baccon J, Pellizzoni L, Rappsilber J, "et al." |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957–62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Carnegie GK, Sleeman JE, Morrice N, "et al." |title=Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1905–13 |year= 2004 |pmid= 12668731 |doi= 10.1242/jcs.00409
*cite journal | author=Di Y, Li J, Zhang Y, "et al." |title=HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. |journal=J. Biochem. |volume=133 |issue= 6 |pages= 713–8 |year= 2004 |pmid= 12869526 |doi=
*cite journal | author=Wan D, He M, Wang J, "et al." |title=Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B. |journal=Genes Chromosomes Cancer |volume=39 |issue= 1 |pages= 48–58 |year= 2004 |pmid= 14603441 |doi= 10.1002/gcc.10293
*cite journal | author=Nelson PT, Hatzigeorgiou AG, Mourelatos Z |title=miRNP:mRNA association in polyribosomes in a human neuronal cell line. |journal=RNA |volume=10 |issue= 3 |pages= 387–94 |year= 2004 |pmid= 14970384 |doi=
*cite journal | author=Shpargel KB, Matera AG |title=Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 48 |pages= 17372–7 |year= 2006 |pmid= 16301532 |doi= 10.1073/pnas.0508947102
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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