- NISCH
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Nischarin Identifiers Symbols NISCH; FLJ14425; FLJ40413; FLJ90519; I-1; IRAS; KIAA0975 External IDs HomoloGene: 5201 GeneCards: NISCH Gene Gene Ontology Molecular function • receptor activity
• integrin binding
• phosphatidylinositol bindingCellular component • cytoplasm
• early endosome
• cytosol
• plasma membrane
• recycling endosomeBiological process • apoptosis
• cell communication
• Rac protein signal transduction
• actin cytoskeleton organization
• negative regulation of cell migrationSources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 11188 64652 Ensembl ENSG00000010322 ENSMUSG00000021910 UniProt Q9Y2I1 n/a RefSeq (mRNA) NM_007184 NM_022656.2 RefSeq (protein) NP_009115 NP_073147.2 Location (UCSC) Chr 3:
52.49 – 52.53 MbChr 14:
31.98 – 32.03 MbPubMed search [1] [2] Nischarin is a protein that in humans is encoded by the NISCH gene.[1][2][3]
Contents
Interactions
NISCH has been shown to interact with IRS4.[1]
See also
References
- ^ a b Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J Biol Chem 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
- ^ Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ (Jul 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA Cell Biol 19 (6): 319–29. doi:10.1089/10445490050043290. PMID 10882231.
- ^ "Entrez Gene: NISCH nischarin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11188.
Further reading
- Ivanov TR, Jones JC, Dontenwill M, et al. (1999). "Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera.". J. Auton. Nerv. Syst. 72 (2–3): 98–110. doi:10.1016/S0165-1838(98)00094-0. PMID 9851558.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- El-Ayoubi R, Gutkowska J, Regunathan S, Mukaddam-Daher S (2002). "Imidazoline receptors in the heart: characterization, distribution, and regulation". J. Cardiovasc. Pharmacol. 39 (6): 875–83. doi:10.1097/00005344-200206000-00013. PMID 12021582.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Edwards L, Ernsberger P (2003). "The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase". Brain Res. 980 (1): 71–9. doi:10.1016/S0006-8993(03)02893-2. PMID 12865160.
- Dontenwill M, Pascal G, Piletz JE, et al. (2004). "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells". Cell Death Differ. 10 (8): 933–5. doi:10.1038/sj.cdd.4401275. PMID 12868002.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dontenwill M, Piletz JE, Chen M, et al. (2004). "IRAS is an anti-apoptotic protein". Ann. N. Y. Acad. Sci. 1009: 400–12. doi:10.1196/annals.1304.054. PMID 15028619.
- Piletz JE, Deleersnijder W, Roth BL, et al. (2004). "IRAS splice variants". Ann. N. Y. Acad. Sci. 1009: 419–26. doi:10.1196/annals.1304.056. PMID 15028621.
- Chen MJ, Zhu HE, Piletz JE (2004). "Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor". Ann. N. Y. Acad. Sci. 1009: 427–38. doi:10.1196/annals.1304.057. PMID 15028622.
- Zhu H, Hayes J, Chen M, et al. (2004). "Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS". Ann. N. Y. Acad. Sci. 1009: 439–46. doi:10.1196/annals.1304.058. PMID 15028623.
- Lim KP, Hong W (2005). "Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region". J. Biol. Chem. 279 (52): 54770–82. doi:10.1074/jbc.M411315200. PMID 15475348.
- Li F, Wu N, Su RB, et al. (2006). "Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein". J. Cell. Biochem. 98 (6): 1615–28. doi:10.1002/jcb.20806. PMID 16598778.
Categories:- Human proteins
- Chromosome 3 gene stubs
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