- Viral hemorrhagic fever
Viral hemorrhagic fever Classification and external resources ICD-10 A96-A99 eMedicine article/830594 MeSH D006482
The viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses that are caused by four distinct families of RNA viruses: the families Arenaviridae, Filoviridae, Bunyaviridae, and Flaviviridae. All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in extreme cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian nephropathia epidemica, while others, such as the African Ebola virus, can cause severe, life-threatening disease.
- The family Arenaviridae include the viruses responsible for Lassa fever and Argentine, Bolivian, Brazilian and Venezuelan hemorrhagic fevers.
- The family Bunyaviridae include the members of the Hantavirus genus that cause hemorrhagic fever with renal syndrome (HFRS), the Crimean-Congo hemorrhagic fever (CCHF) virus from the Nairovirus genus, and the Rift Valley fever (RVF) virus from the Phlebovirus genus.
- The family Filoviridae include Ebola virus and Marburg virus.
- Finally, the family Flaviviridae include dengue, yellow fever, and two viruses in the tick-borne encephalitis group that cause VHF: Omsk hemorrhagic fever virus and Kyasanur Forest disease virus.
Clinical and treatment aspects
Signs and symptoms of VHFs include (by definition) fever and bleeding diathesis. Manifestations of VHF often also include flushing of the face and chest, petechiae, frank bleeding, edema, hypotension, and shock. Malaise, myalgias, headache, vomiting, and diarrhea occur frequently. Definitive diagnosis is usually made at a reference laboratory with advanced biocontainment capabilities.
The findings of laboratory investigation vary somewhat between the viruses but in general there is a decrease in the total white cell count particularly the lymphocytes, a decrease in the platelet count, an increase in the serum liver enzymes and an increase in both the prothrombin (PT) and activated partial thromboplastin times (PTT). The hematocrit may be elevated. The serum urea and creatine may be raised but this is dependent on the hydration status of the patient. The bleeding time tends to be prolonged.
Medical management of VHF patients may require intensive supportive care. Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa fever, RVF, CCHF, and HFRS due to Old World Hantavirus infection) and can be used only under an experimental protocol as investigational new drug (IND) approved by the U.S. Food and Drug Administration (FDA). Interferon may be effective in Argentine or Bolivian hemorrhagic fevers (also available only as IND). Experimental vaccines for other VHFs are not readily available.
Prophylactic (preventive) ribavirin may be effective for some bunyavirus and arenavirus infections (again, available only as IND).
VHF isolation guidelines dictate that all VHF patients (with the exception of dengue patients) should be cared for using strict contact precautions, including hand hygiene, double gloves, gowns, shoe and leg coverings, and faceshield or goggles. Lassa, CCHF, Ebola, and Marburg viruses may be particularly prone to nosocomial (hospital-based) spread. Airborne precautions should be utilized including, at a minimum, a fit-tested, HEPA filter-equipped respirator (such as an N-95 mask), a battery-powered, air-purifying respirator, or a positive pressure supplied air respirator to be worn by personnel coming within six feet of a VHF patient. Multiple patients should be cohorted (sequestered) to a separate building or a ward with an isolated air-handling system. Environmental decontamination is typically accomplished with hypochlorite or phenolic disinfectants. 
The diversity of clinical features seen among the VHF infections probably originates from varying mechanisms of pathogenesis. An immunopathogenic mechanism, for example, has been identified for dengue hemorrhagic fever, which usually occurs among patients previously infected with a heterologous dengue serotype. An influential theory explaining this phenomenon is called “antibody-dependent enhancement.” In contrast, disseminated intravascular coagulation (DIC) is thought to underlie the hemorrhagic features of Rift Valley, Marburg and Ebola fevers. In most VHFs, however, the etiology of the coagulopathy is most likely multifactorial (e.g., hepatic damage, consumptive coagulopathy, primary marrow dysfunction, etc).
The reasons for variation among patients infected with the same virus are unknown but stem from a complex system of virus-host interactions. Moreover, why some infected persons develop full-blown VHF while others do not also remains an unresolved issue. Virulence of the infecting agent clearly plays an important role. The “VHF syndrome” (capillary leak, bleeding diathesis and hemodynamic compromise leading to shock) occurs in a majority of patients manifesting disease from filoviruses, CCHF, and the South American hemorrhagic fever viruses, while it occurs in a small minority of patients with dengue, RVF and Lassa fever.
The VHF viruses are spread in a variety of ways. Some may be transmitted to humans through a respiratory route. Although evidence for a history of “weaponization” (development into a biological weapon) does not exist for many of these viruses, all are considered by military medical planners to have a potential for aerosol dissemination, weaponization, or likelihood for confusion with similar agents that might be weaponized. 
Notable VHF outbreaks
- Cocoliztli in New Mexico 1545.
- Mékambo in Gabon is the site of several outbreaks of Ebola virus disease.
- Orientale, Congo villages of Durba and Watsa were the epicenter of the 1998–2000 outbreak of Marburg virus disease.
- Uíge Province in Angola is the site of world's worst hemorrhagic fever epidemic, which occurred in 2005.
- An VHF outbreak in the village of Mweka, Democratic Republic of the Congo (DRC) that started in August, 2007, and that has killed 103 people (100 adults and three children), has been shown to be caused (at least partially) by Ebola virus.
- Some experts believe that the Black Death of the Middle Ages may have been caused by a VHF and not by the bubonic plague.
- A viral haemorrhagic fever is a possible cause of the Plague of Athens during the Peloponnesian War.
- Biological agent
- List of viruses
- Dr. Matthew Lukwiya (1957–2000)
- C.J. Peters
- ^ Woods, Lt Col Jon B., ed (2005) (PDF). USAMRIID’s Medical Management of Biological Casualties Handbook (6th ed.). Fort Detrick MA: U.S. Army Medical Institute of Infectious Diseases. pp. 143–4. http://www.usamriid.army.mil/education/bluebookpdf/USAMRIID%20BlueBook%206th%20Edition%20-%20Sep%202006.pdf.
- ^ Woods, Op. cit., pg 145.
- ^ Was the Huey Cocoliztli a Haemorrhagic Fever?
- ^ Indigenous Hemorrhagic Fever and The Spanish Conquest
- ^ Acuna-Soto R, Romero LC, Maguire JH (June 2000). "Large Epidemics of Hemorrhagic Fevers in Mexico 1545–1815" (PDF). Am J Trop Med Hyg 62 (6): 733–9. PMID 11304065. http://www.ajtmh.org/cgi/reprint/62/6/733.pdf.
- ^ Acuna-Soto R, Stahle DW, Cleaveland MK, Therrell MD (April 2002). "Megadrought and Megadeath in 16th Century Mexico". Emerg Infect Dis 8 (4). http://www.cdc.gov/ncidod/Eid/vol8no4/01-0175.htm.
- ^ Epidemics in New Spain
- ^ Will Dunham (January 29, 2008). "Black Death did not kill indiscriminately". Reuters.
- ^ Olson PE, Hames CS, Benenson AS, Genovese EN. "The Thucydides syndrome: ebola deja vu? (or ebola reemergent?)" Emerging Infectious Diseases 2(1996):155-156. ISSN 1080-6059.
- Health Protection Agency
- This article includes information that originally came from US Government publications and websites and is in the public domain.
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meningitisDNA virus: JCV (Progressive multifocal leukoencephalopathy)
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acute viral nasopharyngitis/
Digestive system Urogenital Zoonotic viral diseases (A80–B34, 042–079) Arthropod-borneViral hemorrhagic fevers: Crimean-Congo hemorrhagic fever (CCHFV)Colorado tick fever (CTFV) Mammal-borne Hantavirus pulmonary syndrome (ANDV · SNV)ParamyxoviridaeHenipavirus encephalitis (HeV, NiV)Multiple vectorsRabies (RABV)
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Look at other dictionaries:
viral hemorrhagic fever — ▪ pathology any of a variety of highly fatal viral diseases that are characterized by massive external or internal bleeding or bleeding into the skin. Other symptoms vary by the type of viral hemorrhagic fever but often include fever,… … Universalium
viral hemorrhagic fever — noun a group of illnesses caused by a viral infection (usually restricted to a specific geographic area); fever and gastrointestinal symptoms are followed by capillary hemorrhage • Syn: ↑hemorrhagic fever, ↑haemorrhagic fever, ↑viral haemorrhagic … Useful english dictionary
Marburg viral hemorrhagic fever — An acute infection caused by a virus that produces varying degrees of hemorrhage, shock, and sometimes death … Dictionary of microbiology
viral haemorrhagic fever — noun a group of illnesses caused by a viral infection (usually restricted to a specific geographic area); fever and gastrointestinal symptoms are followed by capillary hemorrhage • Syn: ↑hemorrhagic fever, ↑haemorrhagic fever, ↑viral hemorrhagic… … Useful english dictionary
hemorrhagic fever — noun a group of illnesses caused by a viral infection (usually restricted to a specific geographic area); fever and gastrointestinal symptoms are followed by capillary hemorrhage • Syn: ↑haemorrhagic fever, ↑viral hemorrhagic fever, ↑viral… … Useful english dictionary
hemorrhagic fever — n. any of various acute viral infections, as dengue, yellow fever, or Ebola, characterized by fever, fatigue, internal bleeding, headache, etc … English World dictionary
Omsk hemorrhagic fever — Classification and external resources ICD 10 A98.1 ICD 9 065.1 … Wikipedia
Argentine hemorrhagic fever — noun hemorrhagic fever with neurological signs; caused by the Junin virus • Hypernyms: ↑hemorrhagic fever, ↑haemorrhagic fever, ↑viral hemorrhagic fever, ↑viral haemorrhagic fever, ↑VHF … Useful english dictionary
Marburg hemorrhagic fever — noun a viral disease of green monkeys caused by the Marburg virus; when transmitted to humans it causes serious or fatal illness • Syn: ↑Marburg disease, ↑green monkey disease • Hypernyms: ↑hemorrhagic fever, ↑haemorrhagic fever, ↑viral… … Useful english dictionary
Ebola hemorrhagic fever — noun a severe and often fatal disease in humans and nonhuman primates (monkeys and chimpanzees) caused by the Ebola virus; characterized by high fever and severe internal bleeding; can be spread from person to person; is largely limited to Africa … Useful english dictionary