Sel-12 is a
geneand proteinof the worm " Caenorhabditis elegans". It is a transmembrane proteinand an ortholog of the protein presenilinin humans . It plays a role in the development of the worm's gonads ( vulva) (the worm is a hermaphrodite ). Some mutations in sel-12 cause an egg-laying defect. Sel-12 regulates the proteins lin-12and glp-1 ( glucagon-like peptide-1) analogous to the notch-pathway. Sel-12 plays a role in thermotaxis ( the worm prefers a certain temperature and moves accordingly).
* Stefan Eimer, PhD Thesis LMU Munich/Germany, 2003 "Analysis and suppression of mutant sel-12 in C. elegans "
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