Origin recognition complex, subunit 3
External IDs OMIM604972 MGI1354944 HomoloGene8225 GeneCards: ORC3 Gene
RNA expression pattern
PBB GE ORC3L 210028 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23595 50793
Ensembl ENSG00000135336 ENSMUSG00000040044
UniProt Q9UBD5 Q3ULT0
RefSeq (mRNA) NM_001197259.1 NM_015824
RefSeq (protein) NP_001184188.1 NP_056639
Location (UCSC) Chr 6:
88.3 – 88.38 Mb
Chr 4:
34.52 – 34.56 Mb
PubMed search [1] [2]

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3L gene.[1][2][3]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[3]


ORC3L has been shown to interact with ORC2L,[4][5][6][2][7] MCM7,[4] ORC4L,[5][2][7] ORC5L,[4][5][2][7] MCM4[4] and ORC6L.[4][7]


  1. ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Jan 1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". J Biol Chem 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972. 
  2. ^ a b c d Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (Jul 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. 
  3. ^ a b "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23595. 
  4. ^ a b c d e Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b c Dhar, S K; Delmolino L, Dutta A (Aug. 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  6. ^ Matsuoka, Shuhei; Ballif Bryan A, Smogorzewska Agata, McDonald E Robert, Hurov Kristen E, Luo Ji, Bakalarski Corey E, Zhao Zhenming, Solimini Nicole, Lerenthal Yaniv, Shiloh Yosef, Gygi Steven P, Elledge Stephen J (May. 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science (United States) 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332. 
  7. ^ a b c d Vashee, S; Simancek P, Challberg M D, Kelly T J (Jul. 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 

Further reading

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Look at other dictionaries:

  • ORC2L — Origin recognition complex, subunit 2 Identifiers Symbols ORC2; ORC2 External IDs OM …   Wikipedia

  • ORC4L — Origin recognition complex, subunit 4 Identifiers Symbols ORC4; FLJ46668; ORC4L; ORC4P External IDs …   Wikipedia

  • ORC6L — Origin recognition complex, subunit 6 Identifiers Symbols ORC6; ORC6 External IDs O …   Wikipedia

  • ORC5L — Origin recognition complex, subunit 5 Identifiers Symbols ORC5; ORC5L; ORC5P; ORC5T External IDs …   Wikipedia

  • MCM7 — Proteína 7 de mantenimiento de mini cromosomas (S. cerevisiae) HUGO 6950 Símbolo MCM7 Símbolos alt. MCM2; CDA …   Wikipedia Español