- NTN1
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Netrin 1 Identifiers Symbols NTN1; NTN1L External IDs OMIM: 601614 MGI: 105088 HomoloGene: 21008 GeneCards: NTN1 Gene Gene Ontology Molecular function • protein binding Cellular component • extracellular region
• extracellular region
• basement membrane
• cytoplasmBiological process • neuron migration
• apoptosis
• axon guidance
• positive regulation of cell proliferation
• cell-cell adhesion
• regulation of cell migration
• negative regulation of axon extension
• mammary gland development
• establishment of nucleus localization
• positive regulation of axon extension
• mammary gland duct morphogenesisSources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9423 18208 Ensembl ENSG00000065320 ENSMUSG00000020902 UniProt O95631 Q5SSV4 RefSeq (mRNA) NM_004822 NM_008744.2 RefSeq (protein) NP_004813 NP_032770.2 Location (UCSC) Chr 17:
8.92 – 9.15 MbChr 11:
68.02 – 68.21 MbPubMed search [1] [2] Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[1][2]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[2]
Interactions
NTN1 has been shown to interact with Deleted in Colorectal Cancer.[1][3]
References
- ^ a b Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (Apr 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ 10 (1): 35–42. PMID 9950216.
- ^ a b "Entrez Gene: NTN1 netrin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9423.
- ^ Geisbrecht, Brian V; Dowd Kimberly A, Barfield Ronald W, Longo Patti A, Leahy Daniel J (Aug. 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. (United States) 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718.
Further reading
- Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis.". Nat. Rev. Cancer 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
- Mehlen P, Furne C (2006). "Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis.". Cell. Mol. Life Sci. 62 (22): 2599–616. doi:10.1007/s00018-005-5191-3. PMID 16158190.
- Keino-Masu K, Masu M, Hinck L, et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.". Cell 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
- Serafini T, Colamarino SA, Leonardo ED, et al. (1997). "Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.". Cell 87 (6): 1001–14. doi:10.1016/S0092-8674(00)81795-X. PMID 8978605.
- Togari A, Mogi M, Arai M, et al. (2001). "Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts.". Brain Res. 878 (1–2): 204–9. doi:10.1016/S0006-8993(00)02700-1. PMID 10996153.
- Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor". Nature 407 (6805): 747–50. doi:10.1038/35037600. PMID 11048721.
- Manitt C, Colicos MA, Thompson KM, et al. (2001). "Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord". J. Neurosci. 21 (11): 3911–22. PMID 11356879.
- Srinivasan K, Strickland P, Valdes A, et al. (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
- Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
- Yebra M, Montgomery AM, Diaferia GR, et al. (2003). "Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration". Dev. Cell 5 (5): 695–707. doi:10.1016/S1534-5807(03)00330-7. PMID 14602071.
- Mazelin L, Bernet A, Bonod-Bidaud C, et al. (2004). "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis". Nature 431 (7004): 80–4. doi:10.1038/nature02788. PMID 15343335.
- Kato HD, Kondoh H, Inoue T, et al. (2004). "Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis". Gynecol. Oncol. 95 (2): 281–9. doi:10.1016/j.ygyno.2004.07.050. PMID 15491747.
- Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMID 15574733.
- Hérincs Z, Corset V, Cahuzac N, et al. (2005). "DCC association with lipid rafts is required for netrin-1-mediated axon guidance". J. Cell. Sci. 118 (Pt 8): 1687–92. doi:10.1242/jcs.02296. PMID 15811950.
- Kim TH, Lee HK, Seo IA, et al. (2005). "Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron". J. Neurochem. 95 (1): 1–8. doi:10.1111/j.1471-4159.2005.03314.x. PMC 2683579. PMID 16181408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2683579.
- Ly NP, Komatsuzaki K, Fraser IP, et al. (2006). "Netrin-1 inhibits leukocyte migration in vitro and in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (41): 14729–34. doi:10.1073/pnas.0506233102. PMC 1253572. PMID 16203981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1253572.
Categories:- Human proteins
- Chromosome 17 gene stubs
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