NUP107


NUP107
Nucleoporin 107kDa

Rendering based on PDB 3CQC.
Identifiers
Symbols NUP107; NUP84
External IDs OMIM607617 MGI2143854 HomoloGene5555 GeneCards: NUP107 Gene
RNA expression pattern
PBB GE NUP107 218768 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57122 103468
Ensembl ENSG00000111581 ENSMUSG00000052798
UniProt P57740 Q3TT06
RefSeq (mRNA) NM_020401 NM_134010.2
RefSeq (protein) NP_065134 NP_598771.1
Location (UCSC) Chr 12:
69.08 – 69.14 Mb
Chr 10:
117.19 – 117.23 Mb
PubMed search [1] [2]

Nuclear pore complex protein Nup107 is a protein that in humans is encoded by the NUP107 gene.[1][2][3]

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]

Interactions

NUP107 has been shown to interact with NUP133.[4][5]

References

  1. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proc Natl Acad Sci U S A 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298712. 
  2. ^ Walther TC, Alves A, Pickersgill H, Loiodice I, Hetzer M, Galy V, Hulsmann BB, Kocher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. 
  3. ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57122. 
  4. ^ Loïodice, Isabelle; Alves Annabelle, Rabut Gwénaël, Van Overbeek Megan, Ellenberg Jan, Sibarita Jean-Baptiste, Doye Valérie (Jul. 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell (United States) 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. ISSN 1059-1524. PMC 452587. PMID 15146057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452587. 
  5. ^ Belgareh, N; Rabut G, Baï S W, van Overbeek M, Beaudouin J, Daigle N, Zatsepina O V, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep. 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. (United States) 154 (6): 1147–60. doi:10.1083/jcb.200101081. ISSN 0021-9525. PMC 2150808. PMID 11564755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150808. 

Further reading


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • NUP133 — Nucleoporin 133kDa PDB rendering based on 1xks …   Wikipedia

  • NUP160 — Nucleoporin 160kDa Identifiers Symbols NUP160; DKFZp686M14102; MGC150678; MGC150679 External IDs …   Wikipedia

  • NUP85 — Nucleoporin 85kDa Identifiers Symbols NUP85; FLJ12549; Nup75 External IDs OMIM:& …   Wikipedia

  • NUP43 — Nucleoporin 43kDa Identifiers Symbols NUP43; FLJ13287; bA350J20.1; p42 External IDs …   Wikipedia

  • Nucleoporin — 220px Structure of nucleoporin Nup107/Nup133 interaction complex, delta finger mutant. Identifiers Symbol Nucleoporin Pfam PF03177 …   Wikipedia

  • NUP98 — Nucleoporin 98kDa PDB rendering based on 1ko6 …   Wikipedia

  • NUP37 — nucleoporin 37kDa Identifiers Symbol NUP37 Entrez 79023 HUGO …   Wikipedia

  • Cell nucleus — HeLa cells stained for the cell nucleus DNA with the Blue Hoechst dye. The central and rightmost cell are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed ready for… …   Wikipedia

  • Chromatin — The major structures in DNA compaction; DNA, the nucleosome, the 10nm beads on a string fibre, the 30nm fibre and the metaphase chromosome Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The… …   Wikipedia

  • Centromere — Chromosomal components: (1) Chromatid (2) Centromere (3) Short arm (4) Long arm A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come closest in contact. It is involved in cell… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.