Nucleoporin 107kDa

Rendering based on PDB 3CQC.
Symbols NUP107; NUP84
External IDs OMIM607617 MGI2143854 HomoloGene5555 GeneCards: NUP107 Gene
RNA expression pattern
PBB GE NUP107 218768 at tn.png
More reference expression data
Species Human Mouse
Entrez 57122 103468
Ensembl ENSG00000111581 ENSMUSG00000052798
UniProt P57740 Q3TT06
RefSeq (mRNA) NM_020401 NM_134010.2
RefSeq (protein) NP_065134 NP_598771.1
Location (UCSC) Chr 12:
69.08 – 69.14 Mb
Chr 10:
117.19 – 117.23 Mb
PubMed search [1] [2]

Nuclear pore complex protein Nup107 is a protein that in humans is encoded by the NUP107 gene.[1][2][3]

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]


NUP107 has been shown to interact with NUP133.[4][5]


  1. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proc Natl Acad Sci U S A 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102. 
  2. ^ Walther TC, Alves A, Pickersgill H, Loiodice I, Hetzer M, Galy V, Hulsmann BB, Kocher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. 
  3. ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa". 
  4. ^ Loïodice, Isabelle; Alves Annabelle, Rabut Gwénaël, Van Overbeek Megan, Ellenberg Jan, Sibarita Jean-Baptiste, Doye Valérie (Jul. 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell (United States) 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. ISSN 1059-1524. PMC 452587. PMID 15146057. 
  5. ^ Belgareh, N; Rabut G, Baï S W, van Overbeek M, Beaudouin J, Daigle N, Zatsepina O V, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep. 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. (United States) 154 (6): 1147–60. doi:10.1083/jcb.200101081. ISSN 0021-9525. PMC 2150808. PMID 11564755. 

Further reading

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