Microsomal glutathione S-transferase 1

Microsomal glutathione S-transferase 1
Microsomal glutathione S-transferase 1
Identifiers
Symbols MGST1; GST12; MGC14525; MGST; MGST-I
External IDs OMIM138330 MGI1913850 HomoloGene10544 GeneCards: MGST1 Gene
EC number 2.5.1.18
Orthologs
Species Human Mouse
Entrez 4257 56615
Ensembl ENSG00000008394 ENSMUSG00000008540
UniProt P10620 Q53ZD4
RefSeq (mRNA) NM_020300.3 NM_019946.4
RefSeq (protein) NP_064696.1 NP_064330.2
Location (UCSC) Chr 12:
16.5 – 16.76 Mb
Chr 6:
138.09 – 138.11 Mb
PubMed search [1] [2]

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.[1]

Function

The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.[1]

References

Further reading


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