NUP50


NUP50
Nucleoporin 50kDa
Identifiers
Symbols NUP50; MGC39961; NPAP60; NPAP60L
External IDs OMIM604646 MGI1351502 HomoloGene5190 GeneCards: NUP50 Gene
RNA expression pattern
PBB GE NUP50 218294 s at tn.png
PBB GE NUP50 213682 at tn.png
PBB GE NUP50 218293 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10762 18141
Ensembl ENSG00000093000 ENSMUSG00000016619
UniProt Q9UKX7 Q3TG43
RefSeq (mRNA) NM_007172.3 NM_016714.2
RefSeq (protein) NP_009103.2 NP_057923.2
Location (UCSC) Chr 22:
45.56 – 45.58 Mb
Chr 15:
84.75 – 84.77 Mb
PubMed search [1] [2]

Nucleoporin 50 kDa is a protein that in humans is encoded by the NUP50 gene.[1][2]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

NUP50 has been shown to interact with KPNB1[3] and CDKN1B.[4]

References

  1. ^ Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE (Oct 1999). "Mapping and complex expression pattern of the human NPAP60L nucleoporin gene". Cytogenet Cell Genet 85 (3–4): 221–6. doi:10.1159/000015297. PMID 10449902. 
  2. ^ a b "Entrez Gene: NUP50 nucleoporin 50kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10762. 
  3. ^ Lindsay, Mark E; Plafker Kendra, Smith Alicia E, Clurman Bruce E, Macara Ian G (Aug. 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell (United States) 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. 
  4. ^ Smitherman, M; Lee K, Swanger J, Kapur R, Clurman B E (Aug. 2000). "Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex". Mol. Cell. Biol. (UNITED STATES) 20 (15): 5631–42. doi:10.1128/MCB.20.15.5631-5642.2000. ISSN 0270-7306. PMC 86029. PMID 10891500. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86029. 

Further reading


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Nucleoporin — 220px Structure of nucleoporin Nup107/Nup133 interaction complex, delta finger mutant. Identifiers Symbol Nucleoporin Pfam PF03177 …   Wikipedia

  • CDKN1B — Cyclin dependent kinase inhibitor 1B (p27, Kip1) PDB rendering based on 1jsu …   Wikipedia

  • KPNB1 — Karyopherin (importin) beta 1 PDB rendering based on 1f59 …   Wikipedia

  • CDKN1B — Inhibidor 1B de quinasa dependiente de ciclina Estructura tridimensional de la proteína CDKN1B. HUGO …   Wikipedia Español

  • Cell nucleus — HeLa cells stained for the cell nucleus DNA with the Blue Hoechst dye. The central and rightmost cell are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed ready for… …   Wikipedia

  • Chromatin — The major structures in DNA compaction; DNA, the nucleosome, the 10nm beads on a string fibre, the 30nm fibre and the metaphase chromosome Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The… …   Wikipedia

  • Centromere — Chromosomal components: (1) Chromatid (2) Centromere (3) Short arm (4) Long arm A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come closest in contact. It is involved in cell… …   Wikipedia

  • Nuclear pore — Diagram of human cell nucleus. Nuclear pore labeled at bottom left …   Wikipedia

  • Nucleolus — The nucleolus is contained within the cell nucleus …   Wikipedia

  • Topoisomerase — Topoisomerases (type I: EC 5.99.1.2, type II: EC 5.99.1.3) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure. For example, during DNA… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.