CHP (gene)

Calcium binding protein P22, also known as CHP, is a human gene.cite web | title = Entrez Gene: CHP calcium binding protein P22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11261| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a phosphoprotein that binds to the sodium-potassium exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.cite web | title = Entrez Gene: CHP calcium binding protein P22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11261| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Barroso MR, Bernd KK, DeWitt ND, "et al." |title=A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10183–7 |year= 1996 |pmid= 8626580 |doi=
*cite journal | author=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=
*cite journal | author=Lin X, Sikkink RA, Rusnak F, Barber DL |title=Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36125–31 |year= 2000 |pmid= 10593895 |doi=
*cite journal | author=Pang T, Su X, Wakabayashi S, Shigekawa M |title=Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17367–72 |year= 2001 |pmid= 11350981 |doi= 10.1074/jbc.M100296200
*cite journal | author=Matsumoto M, Miyake Y, Nagita M, "et al." |title=A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. |journal=J. Biochem. |volume=130 |issue= 2 |pages= 217–25 |year= 2001 |pmid= 11481038 |doi=
*cite journal | author=Nakamura N, Miyake Y, Matsushita M, "et al." |title=KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles. |journal=J. Biochem. |volume=132 |issue= 3 |pages= 483–91 |year= 2003 |pmid= 12204119 |doi=
*cite journal | author=Pang T, Wakabayashi S, Shigekawa M |title=Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43771–7 |year= 2003 |pmid= 12226101 |doi= 10.1074/jbc.M208313200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Inoue H, Nakamura Y, Nagita M, "et al." |title=Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. |journal=Biol. Pharm. Bull. |volume=26 |issue= 2 |pages= 148–55 |year= 2003 |pmid= 12576672 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Pang T, Hisamitsu T, Mori H, "et al." |title=Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements. |journal=Biochemistry |volume=43 |issue= 12 |pages= 3628–36 |year= 2004 |pmid= 15035633 |doi= 10.1021/bi0360004
*cite journal | author=Andrade J, Pearce ST, Zhao H, Barroso M |title=Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules. |journal=Biochem. J. |volume=384 |issue= Pt 2 |pages= 327–36 |year= 2005 |pmid= 15312048 |doi= 10.1042/BJ20040622
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ben Ammar Y, Takeda S, Sugawara M, "et al." |title=Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=61 |issue= Pt 10 |pages= 956–8 |year= 2006 |pmid= 16511206 |doi= 10.1107/S1744309105030836
*cite journal | author=Mishima M, Wakabayashi S, Kojima C |title=Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. |journal=J. Biol. Chem. |volume=282 |issue= 4 |pages= 2741–51 |year= 2007 |pmid= 17050540 |doi= 10.1074/jbc.M604092200

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