JMJD2A

Jumonji domain containing 2A, also known as JMJD2A, is a human gene.cite web | title = Entrez Gene: JMJD2A jumonji domain containing 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9682| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.cite web | title = Entrez Gene: JMJD2A jumonji domain containing 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9682| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yoon HG, Chan DW, Reynolds AB, "et al." |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723–34 |year= 2003 |pmid= 14527417 |doi=
*cite journal | author=Katoh M, Katoh M |title=Identification and characterization of JMJD2 family genes in silico. |journal=Int. J. Oncol. |volume=24 |issue= 6 |pages= 1623–8 |year= 2004 |pmid= 15138608 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gray SG, Iglesias AH, Lizcano F, "et al." |title=Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28507–18 |year= 2005 |pmid= 15927959 |doi= 10.1074/jbc.M413687200
*cite journal | author=Zhang D, Yoon HG, Wong J |title=JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6404–14 |year= 2005 |pmid= 16024779 |doi= 10.1128/MCB.25.15.6404-6414.2005
*cite journal | author=Tao WA, Wollscheid B, O'Brien R, "et al." |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776
*cite journal | author=Kim J, Daniel J, Espejo A, "et al." |title=Tudor, MBT and chromo domains gauge the degree of lysine methylation. |journal=EMBO Rep. |volume=7 |issue= 4 |pages= 397–403 |year= 2006 |pmid= 16415788 |doi= 10.1038/sj.embor.7400625
*cite journal | author=Huang Y, Fang J, Bedford MT, "et al." |title=Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. |journal=Science |volume=312 |issue= 5774 |pages= 748–51 |year= 2006 |pmid= 16601153 |doi= 10.1126/science.1125162
*cite journal | author=Whetstine JR, Nottke A, Lan F, "et al." |title=Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. |journal=Cell |volume=125 |issue= 3 |pages= 467–81 |year= 2006 |pmid= 16603238 |doi= 10.1016/j.cell.2006.03.028
*cite journal | author=Chen Z, Zang J, Whetstine J, "et al." |title=Structural insights into histone demethylation by JMJD2 family members. |journal=Cell |volume=125 |issue= 4 |pages= 691–702 |year= 2006 |pmid= 16677698 |doi= 10.1016/j.cell.2006.04.024
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Klose RJ, Yamane K, Bae Y, "et al." |title=The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. |journal=Nature |volume=442 |issue= 7100 |pages= 312–6 |year= 2006 |pmid= 16732292 |doi= 10.1038/nature04853
*cite journal | author=Shin S, Janknecht R |title=Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 3 |pages= 742–6 |year= 2007 |pmid= 17555712 |doi= 10.1016/j.bbrc.2007.05.179
*cite journal | author=Chen Z, Zang J, Kappler J, "et al." |title=Structural basis of the recognition of a methylated histone tail by JMJD2A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 26 |pages= 10818–23 |year= |pmid= 17567753 |doi= 10.1073/pnas.0704525104
*cite journal | author=Ng SS, Kavanagh KL, McDonough MA, "et al." |title=Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. |journal=Nature |volume=448 |issue= 7149 |pages= 87–91 |year= 2007 |pmid= 17589501 |doi= 10.1038/nature05971
*cite journal | author=Lee J, Thompson JR, Botuyan MV, "et al." |title=Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. |journal=Nat. Struct. Mol. Biol. |volume=15 |issue= q |pages= 109–111 |year= 2008 |pmid= 18084306 |doi= 10.1038/nsmb1326

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