FABP7

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.cite web | title = Entrez Gene: FABP7 fatty acid binding protein 7, brain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2173| accessdate = ] PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.cite web | title = Entrez Gene: FABP7 fatty acid binding protein 7, brain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2173| accessdate = ]

FABP7 is expressed in radial glia by the activation of Notch receptors. cite journal |author=Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N |title=Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells |journal=Genes Dev. |volume=19 |issue=9 |pages=1028–33 |year=2005 |month=May |pmid=15879553 |pmc=1091737 |doi=10.1101/gad.1302105 |url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=15879553] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation. cite journal |author=Keilani S, Sugaya K |title=Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 |journal=BMC Dev. Biol. |volume=8 |issue=1 |pages=69 |year=2008 |month=July |pmid=18593473 |doi=10.1186/1471-213X-8-69 |url=http://www.biomedcentral.com/1471-213X/8/69]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs. cite journal |author=Xu LZ, Sánchez R, Sali A, Heintz N |title=Ligand specificity of brain lipid-binding protein |journal=J. Biol. Chem. |volume=271 |issue=40 |pages=24711–9 |year=1996 |month=October |pmid=8798739 |doi= |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8798739]

Role in pathology

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis. cite journal |author=Lewis CM, Levinson DF, Wise LH, "et al" |title=Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia |journal=Am. J. Hum. Genet. |volume=73 |issue=1 |pages=34–48 |year=2003 |month=July |pmid=12802786 |pmc=1180588 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/AJHG024834]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia, [http://www.schizophreniaforum.org/res/sczgene/geneoverview.asp?geneID=594 Gene Overview of All Published Schizophrenia-Association Studies for FABP7] - SZGene database at Schizophrenia Research Forum website.] with one, that tested for only one SNP, showing negative cite journal |author=Jungerius BJ, Hoogendoorn ML, Bakker SC, "et al" |title=An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia |journal=Mol. Psychiatry |volume= |issue= |pages= |year=2007 |month=September |pmid=17893707 |doi=10.1038/sj.mp.4002080 |url=http://dx.doi.org/10.1038/sj.mp.4002080] and another, with seven SNPs, cite journal |author=Watanabe A, Toyota T, Owada Y, "et al" |title=Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype |journal=PLoS Biol. |volume=5 |issue=11 |pages=e297 |year=2007 |month=November |pmid=18001149 |pmc=2071943 |doi=10.1371/journal.pbio.0050297 |url=http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050297] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Börchers T, Hohoff C, Buhlmann C, Spener F |title=Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 77–84 |year= 1997 |pmid= 9250612 |doi=
*cite journal | author=Xu LZ, Sánchez R, Sali A, Heintz N |title=Ligand specificity of brain lipid-binding protein. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24711–9 |year= 1996 |pmid= 8798739 |doi=
*cite journal | author=Young JK, Baker JH, Muller T |title=Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes. |journal=Glia |volume=16 |issue= 3 |pages= 218–26 |year= 1997 |pmid= 8833192 |doi= 10.1002/(SICI)1098-1136(199603)16:3<218::AID-GLIA4>3.0.CO;2-Y
*cite journal | author=Shi YE, Ni J, Xiao G, "et al." |title=Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. |journal=Cancer Res. |volume=57 |issue= 15 |pages= 3084–91 |year= 1997 |pmid= 9242429 |doi=
*cite journal | author=Shimizu F, Watanabe TK, Shinomiya H, "et al." |title=Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). |journal=Biochim. Biophys. Acta |volume=1354 |issue= 1 |pages= 24–8 |year= 1997 |pmid= 9375786 |doi=
*cite journal | author=Godbout R, Bisgrove DA, Shkolny D, Day RS |title=Correlation of B-FABP and GFAP expression in malignant glioma. |journal=Oncogene |volume=16 |issue= 15 |pages= 1955–62 |year= 1998 |pmid= 9591779 |doi= 10.1038/sj.onc.1201740
*cite journal | author=Pu L, Igbavboa U, Wood WG, "et al." |title=Expression of fatty acid binding proteins is altered in aged mouse brain. |journal=Mol. Cell. Biochem. |volume=198 |issue= 1-2 |pages= 69–78 |year= 1999 |pmid= 10497880 |doi=
*cite journal | author=Balendiran GK, Schnutgen F, Scapin G, "et al." |title=Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27045–54 |year= 2000 |pmid= 10854433 |doi= 10.1074/jbc.M003001200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rademacher M, Zimmerman AW, Rüterjans H, "et al." |title=Solution structure of fatty acid-binding protein from human brain. |journal=Mol. Cell. Biochem. |volume=239 |issue= 1-2 |pages= 61–8 |year= 2003 |pmid= 12479569 |doi=
*cite journal | author=Miller SJ, Li H, Rizvi TA, "et al." |title=Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2213–24 |year= 2003 |pmid= 12612091 |doi=
*cite journal | author=Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G |title=Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2769–77 |year= 2003 |pmid= 12771203 |doi=
*cite journal | author=Wang M, Liu YE, Goldberg ID, Shi YE |title=Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47319–25 |year= 2004 |pmid= 12975368 |doi= 10.1074/jbc.M308131200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liang Y, Diehn M, Watson N, "et al." |title=Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 16 |pages= 5814–9 |year= 2005 |pmid= 15827123 |doi= 10.1073/pnas.0402870102
*cite journal | author=Liang Y, Bollen AW, Aldape KD, Gupta N |title=Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. |journal=BMC Cancer |volume=6 |issue= |pages= 97 |year= 2006 |pmid= 16623952 |doi= 10.1186/1471-2407-6-97
*cite journal | author=Kaloshi G, Mokhtari K, Carpentier C, "et al." |title=FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status. |journal=J. Neurooncol. |volume=84 |issue= 3 |pages= 245–8 |year= 2007 |pmid= 17415524 |doi= 10.1007/s11060-007-9377-4

External links

* [http://www.schizophrenia.com/sznews/archives/005778.html Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers?] Schizophrenia Daily News Blog, 2007-11-07
* [http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050320 Gross L (2007) A Candidate Gene for a Biological Marker of Schizophrenia in Mice. PLoS Biol 5(11): e320 doi:10.1371/journal.pbio.0050320] - a synopsis for the general audience.

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