LMO1

LIM domain only 1 (rhombotin 1), also known as LMO1, is a human gene.cite web | title = Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4004| accessdate = ]

PBB_Summary
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summary_text = LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.cite web | title = Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4004| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Foroni L, Boehm T, White L, "et al." |title=The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. |journal=J. Mol. Biol. |volume=226 |issue= 3 |pages= 747–61 |year= 1992 |pmid= 1507224 |doi=
*cite journal | author=McGuire EA, Davis AR, Korsmeyer SJ |title=T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. |journal=Blood |volume=77 |issue= 3 |pages= 599–606 |year= 1991 |pmid= 1703797 |doi=
*cite journal | author=Boehm T, Foroni L, Kaneko Y, "et al." |title=The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 10 |pages= 4367–71 |year= 1991 |pmid= 2034676 |doi=
*cite journal | author=Boehm T, Spillantini MG, Sofroniew MV, "et al." |title=Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. |journal=Oncogene |volume=6 |issue= 5 |pages= 695–703 |year= 1991 |pmid= 2052354 |doi=
*cite journal | author=Chen Q, Cheng JT, Tasi LH, "et al." |title=The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. |journal=EMBO J. |volume=9 |issue= 2 |pages= 415–24 |year= 1990 |pmid= 2303035 |doi=
*cite journal | author=Boehm T, Greenberg JM, Buluwela L, "et al." |title=An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. |journal=EMBO J. |volume=9 |issue= 3 |pages= 857–68 |year= 1990 |pmid= 2311586 |doi=
*cite journal | author=McGuire EA, Hockett RD, Pollock KM, "et al." |title=The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. |journal=Mol. Cell. Biol. |volume=9 |issue= 5 |pages= 2124–32 |year= 1989 |pmid= 2501659 |doi=
*cite journal | author=Boehm T, Baer R, Lavenir I, "et al." |title=The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. |journal=EMBO J. |volume=7 |issue= 2 |pages= 385–94 |year= 1988 |pmid= 3259177 |doi=
*cite journal | author=Wadman I, Li J, Bash RO, "et al." |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=
*cite journal | author=Valge-Archer VE, Osada H, Warren AJ, "et al." |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617–21 |year= 1994 |pmid= 8078932 |doi=
*cite journal | author=Arber S, Caroni P |title=Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. |journal=Genes Dev. |volume=10 |issue= 3 |pages= 289–300 |year= 1996 |pmid= 8595880 |doi=
*cite journal | author=Jurata LW, Kenny DA, Gill GN |title=Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11693–8 |year= 1996 |pmid= 8876198 |doi=
*cite journal | author=Ono Y, Fukuhara N, Yoshie O |title=Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4576–81 |year= 1997 |pmid= 9020185 |doi=
*cite journal | author=Valge-Archer V, Forster A, Rabbitts TH |title=The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). |journal=Oncogene |volume=17 |issue= 24 |pages= 3199–202 |year= 1999 |pmid= 9872335 |doi= 10.1038/sj.onc.1202353
*cite journal | author=Bao J, Talmage DA, Role LW, Gautier J |title=Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. |journal=Development |volume=127 |issue= 2 |pages= 425–35 |year= 2000 |pmid= 10603358 |doi=
*cite journal | author=Cichutek A, Brueckmann T, Seipel B, "et al." |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3-4 |pages= 277–83 |year= 2001 |pmid= 11528126 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lin YW, Deveney R, Barbara M, "et al." |title=OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7151–8 |year= 2005 |pmid= 16103065 |doi= 10.1158/0008-5472.CAN-05-1400
*cite journal | author=Saeki N, Kim DH, Usui T, "et al." |title=GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. |journal=Oncogene |volume=26 |issue= 45 |pages= 6488–98 |year= 2007 |pmid= 17471240 |doi= 10.1038/sj.onc.1210475

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