- HARS
Histidyl-tRNA synthetase, also known as HARS, is a human
gene .cite web | title = Entrez Gene: HARS histidyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3035| accessdate = ]PBB_Summary
section_title =
summary_text = Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.cite web | title = Entrez Gene: HARS histidyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3035| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Raben N, Borriello F, Amin J, "et al." |title=Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. |journal=Nucleic Acids Res. |volume=20 |issue= 5 |pages= 1075–81 |year= 1992 |pmid= 1549469 |doi=
*cite journal | author=Shi MH, Tsui FW, Rubin LA |title=Cellular localization of the target structures recognized by the anti-Jo-1 antibody: immunofluorescence studies on cultured human myoblasts. |journal=J. Rheumatol. |volume=18 |issue= 2 |pages= 252–8 |year= 1991 |pmid= 2023220 |doi=
*cite journal | author=Carlock LR, Skarecky D, Dana SL, Wasmuth JJ |title=Deletion mapping of human chromosome 5 using chromosome-specific DNA probes. |journal=Am. J. Hum. Genet. |volume=37 |issue= 5 |pages= 839–52 |year= 1985 |pmid= 2996334 |doi=
*cite journal | author=Wasmuth JJ, Carlock LR |title=Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5. |journal=Somat. Cell Mol. Genet. |volume=12 |issue= 5 |pages= 513–7 |year= 1986 |pmid= 3464104 |doi=
*cite journal | author=Tsui FW, Siminovitch L |title=Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase. |journal=Nucleic Acids Res. |volume=15 |issue= 8 |pages= 3349–67 |year= 1987 |pmid= 3554142 |doi=
*cite journal | author=O'Hanlon TP, Raben N, Miller FW |title=A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. |journal=Biochem. Biophys. Res. Commun. |volume=210 |issue= 2 |pages= 556–66 |year= 1995 |pmid= 7755634 |doi=
*cite journal | author=Ogata K, Kurahashi A, Nishiyama C, Terao K |title=Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. |journal=Biochim. Biophys. Acta |volume=1218 |issue= 3 |pages= 388–400 |year= 1994 |pmid= 8049265 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tsui HW, Mok S, de Souza L, "et al." |title=Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element. |journal=Gene |volume=131 |issue= 2 |pages= 201–8 |year= 1993 |pmid= 8406012 |doi=
*cite journal | author=Vázquez-Abad D, Carson JH, Rothfield N |title=Localization of histidyl-tRNA synthetase (Jo-1) in human laryngeal epithelial carcinoma cell line (HEp-2 cells). |journal=Cell Tissue Res. |volume=286 |issue= 3 |pages= 487–91 |year= 1997 |pmid= 8929351 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Sang Lee J, Gyu Park S, Park H, "et al." |title=Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 1 |pages= 158–64 |year= 2002 |pmid= 11829477 |doi= 10.1006/bbrc.2002.6398
*cite journal | author=O'Hanlon TP, Miller FW |title=Genomic organization, transcriptional mapping, and evolutionary implications of the human bi-directional histidyl-tRNA synthetase locus (HARS/HARSL). |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 3 |pages= 609–14 |year= 2002 |pmid= 12056811 |doi= 10.1016/S0006-291X(02)00525-9
*cite journal | author=Ascherman DP, Oriss TB, Oddis CV, Wright TM |title=Critical requirement for professional APCs in eliciting T cell responses to novel fragments of histidyl-tRNA synthetase (Jo-1) in Jo-1 antibody-positive polymyositis. |journal=J. Immunol. |volume=169 |issue= 12 |pages= 7127–34 |year= 2003 |pmid= 12471150 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lu Q, Hope LW, Brasch M, "et al." |title=TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 13 |pages= 7626–31 |year= 2003 |pmid= 12802020 |doi= 10.1073/pnas.0932599100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Levine SM, Raben N, Xie D, "et al." |title=Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. |journal=Arthritis Rheum. |volume=56 |issue= 8 |pages= 2729–39 |year= 2007 |pmid= 17665459 |doi= 10.1002/art.22790PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
