EPHB3

EPH receptor B3, also known as EPHB3, is a human gene.cite web | title = Entrez Gene: EPHB3 EPH receptor B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2049| accessdate = ]

PBB_Summary
section_title =
summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.cite web | title = Entrez Gene: EPHB3 EPH receptor B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2049| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Böhme B, Holtrich U, Wolf G, "et al." |title=PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. |journal=Oncogene |volume=8 |issue= 10 |pages= 2857–62 |year= 1993 |pmid= 8397371 |doi=
*cite journal | author=Böhme B, VandenBos T, Cerretti DP, "et al." |title=Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24747–52 |year= 1996 |pmid= 8798744 |doi=
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Bergemann AD, Zhang L, Chiang MK, "et al." |title=Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. |journal=Oncogene |volume=16 |issue= 4 |pages= 471–80 |year= 1998 |pmid= 9484836 |doi= 10.1038/sj.onc.1201557
*cite journal | author=Hock B, Böhme B, Karn T, "et al." |title=Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. |journal=Oncogene |volume=17 |issue= 2 |pages= 255–60 |year= 1998 |pmid= 9674711 |doi= 10.1038/sj.onc.1201907
*cite journal | author=Hock B, Böhme B, Karn T, "et al." |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–84 |year= 1998 |pmid= 9707552 |doi=
*cite journal | author=Ciossek T, Monschau B, Kremoser C, "et al." |title=Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. |journal=Eur. J. Neurosci. |volume=10 |issue= 5 |pages= 1574–80 |year= 1998 |pmid= 9751130 |doi=
*cite journal | author=Adams RH, Wilkinson GA, Weiss C, "et al." |title=Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 295–306 |year= 1999 |pmid= 9990854 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes