MAP4K4

Mitogen-activated protein kinase kinase kinase kinase 4, also known as MAP4K4, is a human gene.cite web | title = Entrez Gene: MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9448| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9448| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Su YC, Han J, Xu S, "et al." |title=NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1279–90 |year= 1997 |pmid= 9135144 |doi= 10.1093/emboj/16.6.1279
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Yao Z, Zhou G, Wang XS, "et al." |title=A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2118–25 |year= 1999 |pmid= 9890973 |doi=
*cite journal | author=Becker E, Huynh-Do U, Holland S, "et al." |title=Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1537–45 |year= 2000 |pmid= 10669731 |doi=
*cite journal | author=Zhao ZS, Manser E, Lim L |title=Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3906–17 |year= 2000 |pmid= 10805734 |doi=
*cite journal | author=Hofer-Warbinek R, Schmid JA, Stehlik C, "et al." |title=Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22064–8 |year= 2000 |pmid= 10807933 |doi= 10.1074/jbc.M910346199
*cite journal | author=Chaudhary PM, Eby MT, Jasmin A, "et al." |title=Activation of the NF-kappaB pathway by caspase 8 and its homologs. |journal=Oncogene |volume=19 |issue= 39 |pages= 4451–60 |year= 2000 |pmid= 11002417 |doi= 10.1038/sj.onc.1203812
*cite journal | author=Yan W, Nehrke K, Choi J, Barber DL |title=The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31349–56 |year= 2001 |pmid= 11369779 |doi= 10.1074/jbc.M102679200
*cite journal | author=Poinat P, De Arcangelis A, Sookhareea S, "et al." |title=A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. |journal=Curr. Biol. |volume=12 |issue= 8 |pages= 622–31 |year= 2002 |pmid= 11967148 |doi=
*cite journal | author=Fong A, Zhang M, Neely J, Sun SC |title=S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40697–702 |year= 2002 |pmid= 12185077 |doi= 10.1074/jbc.M205330200
*cite journal | author=Luan Z, Zhang Y, Liu A, "et al." |title=A novel GTP-binding protein hGBP3 interacts with NIK/HGK. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 233–8 |year= 2002 |pmid= 12387898 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wright JH, Wang X, Manning G, "et al." |title=The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2068–82 |year= 2003 |pmid= 12612079 |doi=
*cite journal | author=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Machida N, Umikawa M, Takei K, "et al." |title=Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15711–4 |year= 2004 |pmid= 14966141 |doi= 10.1074/jbc.C300542200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Ballif BA, Villén J, Beausoleil SA, "et al." |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200
*cite journal | author=Collins CS, Hong J, Sapinoso L, "et al." |title=A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 10 |pages= 3775–80 |year= 2006 |pmid= 16537454 |doi= 10.1073/pnas.0600040103
*cite journal | author=Wissing J, Jänsch L, Nimtz M, "et al." |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes