Interleukin 11 receptor alpha subunit

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590| accessdate = ]

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summary_text = Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chérel M, Sorel M, Lebeau B, "et al." |title=Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11. |journal=Blood |volume=86 |issue= 7 |pages= 2534–40 |year= 1995 |pmid= 7670098 |doi=
*cite journal | author=Chérel M, Sorel M, Apiou F, "et al." |title=The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping. |journal=Genomics |volume=32 |issue= 1 |pages= 49–53 |year= 1996 |pmid= 8786120 |doi=
*cite journal | author=Van Leuven F, Stas L, Hilliker C, "et al." |title=Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. |journal=Genomics |volume=31 |issue= 1 |pages= 65–70 |year= 1996 |pmid= 8808281 |doi= 10.1006/geno.1996.0010
*cite journal | author=Magrangeas F, Pitiot G, Dubois S, "et al." |title=Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16005–10 |year= 1998 |pmid= 9632650 |doi=
*cite journal | author=Barton VA, Hudson KR, Heath JK |title=Identification of three distinct receptor binding sites of murine interleukin-11. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5755–61 |year= 1999 |pmid= 10026196 |doi=
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*cite journal | author=Cork BA, Tuckerman EM, Li TC, Laird SM |title=Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro. |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 841–8 |year= 2003 |pmid= 12200462 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
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*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tsimanis A, Shtalrid M, Shvidel L, "et al." |title=Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma. |journal=Leuk. Lymphoma |volume=45 |issue= 11 |pages= 2315–9 |year= 2005 |pmid= 15512823 |doi= 10.1080/10428190412331283161
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Karube K, Ohshima K, Suzumiya J, "et al." |title=Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. |journal=Ann. Oncol. |volume=17 |issue= 1 |pages= 110–6 |year= 2006 |pmid= 16291580 |doi= 10.1093/annonc/mdj064
*cite journal | author=Hanavadi S, Martin TA, Watkins G, "et al." |title=Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer. |journal=Ann. Surg. Oncol. |volume=13 |issue= 6 |pages= 802–8 |year= 2006 |pmid= 16614887 |doi= 10.1245/ASO.2006.05.028
*cite journal | author=Yoshizaki A, Nakayama T, Yamazumi K, "et al." |title=Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. |journal=Int. J. Oncol. |volume=29 |issue= 4 |pages= 869–76 |year= 2006 |pmid= 16964382 |doi=
*cite journal | author=Nakayama T, Yoshizaki A, Izumida S, "et al." |title=Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. |journal=Int. J. Oncol. |volume=30 |issue= 4 |pages= 825–33 |year= 2007 |pmid= 17332920 |doi=

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