VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C, also known as VAPB, is a human gene.cite web | title = Entrez Gene: VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9217| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.cite web | title = Entrez Gene: VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9217| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nishimura Y, Hayashi M, Inada H, Tanaka T |title=Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 1 |pages= 21–6 |year= 1999 |pmid= 9920726 |doi= 10.1006/bbrc.1998.9876
*cite journal | author=Bastepe M, Pincus JE, Jüppner H |title=Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13. |journal=Mol. Cell. Probes |volume=13 |issue= 6 |pages= 449–51 |year= 2000 |pmid= 10657150 |doi= 10.1006/mcpr.1999.0271
*cite journal | author=Paumet F, Le Mao J, Martin S, "et al." |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850–7 |year= 2000 |pmid= 10820264 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. |journal=Blood |volume=100 |issue= 3 |pages= 1081–3 |year= 2002 |pmid= 12130530 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Nishimura AL, Mitne-Neto M, Silva HC, "et al." |title=A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13. |journal=J. Med. Genet. |volume=41 |issue= 4 |pages= 315–20 |year= 2004 |pmid= 15060112 |doi=
*cite journal | author=Nishimura AL, Mitne-Neto M, Silva HC, "et al." |title=A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. |journal=Am. J. Hum. Genet. |volume=75 |issue= 5 |pages= 822–31 |year= 2005 |pmid= 15372378 |doi= 10.1086/425287
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Amarilio R, Ramachandran S, Sabanay H, Lev S |title=Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5934–44 |year= 2005 |pmid= 15545272 |doi= 10.1074/jbc.M409566200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Hamamoto I, Nishimura Y, Okamoto T, "et al." |title=Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. |journal=J. Virol. |volume=79 |issue= 21 |pages= 13473–82 |year= 2005 |pmid= 16227268 |doi= 10.1128/JVI.79.21.13473-13482.2005
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Perry RJ, Ridgway ND |title=Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2604–16 |year= 2006 |pmid= 16571669 |doi= 10.1091/mbc.E06-01-0060
*cite journal | author=Conforti FL, Sprovieri T, Mazzei R, "et al." |title=Sporadic ALS is not associated with VAPB gene mutations in Southern Italy. |journal=Journal of negative results in biomedicine |volume=5 |issue= |pages= 7 |year= 2006 |pmid= 16729899 |doi= 10.1186/1477-5751-5-7
*cite journal | author=Kanekura K, Nishimoto I, Aiso S, Matsuoka M |title=Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 30223–33 |year= 2006 |pmid= 16891305 |doi= 10.1074/jbc.M605049200

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