Syntaxin 3

Syntaxin 3

Syntaxin 3, also known as STX3, is a human gene.cite web | title = Entrez Gene: STX3 syntaxin 3| url =| accessdate = ]

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.cite journal | author = Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F | title = Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1 | journal = J. Leukoc. Biol. | volume = 65 | issue = 3 | pages = 397–406 | year = 1999 | month = March | pmid = 10080545 | doi = | url = | issn = ] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.cite journal | author = Darios F, Davletov B | title = Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3 | journal = Nature | volume = 440 | issue = 7085 | pages = 813–7 | year = 2006 | month = April | pmid = 16598260 | doi = 10.1038/nature04598 | url = | issn = ] Interestingly a N-terminal cleavage product of STX3 interacts very strong with RanBP5 and may act in nuclear signaling and cell polarity. The helices might play an important role in this aspect. STX3 is the only syntaxin which can lack the transmembran domain. An alternatively spliced Syntaxin 1 (STX1B) which lacks the transmembrane domain localizes to the cell nucleus.cite journal | author = Pereira S, Massacrier A, Roll P, Vérine A, Etienne-Grimaldi MC, Poitelon Y, Robaglia-Schlupp A, Jamali S, Roeckel-Trevisiol N, Royer B, Pontarotti P, Lévêque C, Seagar M, Lévy N, Cau P, Szepetowski P | title = Nuclear localization of a novel human syntaxin 1B isoform | journal = Gene | volume = | issue = | pages = | year = 2008 | month = July | pmid = 18691641 | doi = 10.1016/j.gene.2008.07.010 | url = | issn = ]


Further reading

citations =
*cite journal | author=Ibaraki K, Horikawa HP, Morita T, "et al." |title=Identification of four different forms of syntaxin 3. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 3 |pages= 997–1005 |year= 1995 |pmid= 7598732 |doi= 10.1006/bbrc.1995.1910
*cite journal | author=Hata Y, Südhof TC |title=A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13022–8 |year= 1995 |pmid= 7768895 |doi=
*cite journal | author=Li C, Ullrich B, Zhang JZ, "et al." |title=Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. |journal=Nature |volume=375 |issue= 6532 |pages= 594–9 |year= 1995 |pmid= 7791877 |doi= 10.1038/375594a0
*cite journal | author=Morgans CW, Brandstätter JH, Kellerman J, "et al." |title=A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6713–21 |year= 1996 |pmid= 8824312 |doi=
*cite journal | author=Tellam JT, Macaulay SL, McIntosh S, "et al." |title=Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6179–86 |year= 1997 |pmid= 9045631 |doi=
*cite journal | author=Delgrossi MH, Breuza L, Mirre C, "et al." |title=Human syntaxin 3 is localized apically in human intestinal cells. |journal=J. Cell. Sci. |volume=110 ( Pt 18) |issue= |pages= 2207–14 |year= 1997 |pmid= 9378770 |doi=
*cite journal | author=Galli T, Zahraoui A, Vaidyanathan VV, "et al." |title=A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1437–48 |year= 1998 |pmid= 9614185 |doi=
*cite journal | author=Riento K, Galli T, Jansson S, "et al." |title=Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. |journal=J. Cell. Sci. |volume=111 ( Pt 17) |issue= |pages= 2681–8 |year= 1999 |pmid= 9701566 |doi=
*cite journal | author=Steegmaier M, Yang B, Yoo JS, "et al." |title=Three novel proteins of the syntaxin/SNAP-25 family. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34171–9 |year= 1999 |pmid= 9852078 |doi=
*cite journal | author=Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F |title=Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. |journal=J. Leukoc. Biol. |volume=65 |issue= 3 |pages= 397–406 |year= 1999 |pmid= 10080545 |doi=
*cite journal | author=Fasshauer D, Antonin W, Margittai M, "et al." |title=Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15440–6 |year= 1999 |pmid= 10336434 |doi=
*cite journal | author=Thomas DM, Ferguson GD, Herschman HR, Elferink LA |title=Functional and biochemical analysis of the C2 domains of synaptotagmin IV. |journal=Mol. Biol. Cell |volume=10 |issue= 7 |pages= 2285–95 |year= 1999 |pmid= 10397765 |doi=
*cite journal | author=Riento K, Kauppi M, Keranen S, Olkkonen VM |title=Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13476–83 |year= 2000 |pmid= 10788461 |doi=
*cite journal | author=Kauppi M, Wohlfahrt G, Olkkonen VM |title=Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43973–9 |year= 2003 |pmid= 12198139 |doi= 10.1074/jbc.M208315200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597–604 |year= 2003 |pmid= 12828989 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bandyopadhyay BC, Swaim WD, Liu X, "et al." |title=Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12908–16 |year= 2005 |pmid= 15623527 |doi= 10.1074/jbc.M410013200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Low SH, Vasanji A, Nanduri J, "et al." |title=Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 977–89 |year= 2006 |pmid= 16339081 |doi= 10.1091/mbc.E05-05-0462

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