Ring finger protein 1, also known as RING1, is a human gene.cite web | title = Entrez Gene: RING1 ring finger protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015| accessdate = ]

section_title =
summary_text = This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.cite web | title = Entrez Gene: RING1 ring finger protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015| accessdate = ]


Further reading

citations =
*cite journal | author=Hanson IM, Poustka A, Trowsdale J |title=New genes in the class II region of the human major histocompatibility complex. |journal=Genomics |volume=10 |issue= 2 |pages= 417–24 |year= 1991 |pmid= 1906426 |doi=
*cite journal | author=Lovering R, Hanson IM, Borden KL, "et al." |title=Identification and preliminary characterization of a protein motif related to the zinc finger. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2112–6 |year= 1993 |pmid= 7681583 |doi=
*cite journal | author=Satijn DP, Gunster MJ, van der Vlag J, "et al." |title=RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 4105–13 |year= 1997 |pmid= 9199346 |doi=
*cite journal | author=Kikuti YY, Tamiya G, Ando A, "et al." |title=Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. |journal=Genomics |volume=42 |issue= 3 |pages= 422–35 |year= 1997 |pmid= 9205114 |doi= 10.1006/geno.1997.4745
*cite journal | author=Satijn DP, Otte AP |title=RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 57–68 |year= 1999 |pmid= 9858531 |doi=
*cite journal | author=García E, Marcos-Gutiérrez C, del Mar Lorente M, "et al." |title=RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3404–18 |year= 1999 |pmid= 10369680 |doi= 10.1093/emboj/18.12.3404
*cite journal | author=Bárdos JI, Saurin AJ, Tissot C, "et al." |title=HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28785–92 |year= 2000 |pmid= 10825164 |doi= 10.1074/jbc.M001835200
*cite journal | author=Trimarchi JM, Fairchild B, Wen J, Lees JA |title=The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1519–24 |year= 2001 |pmid= 11171983 |doi= 10.1073/pnas.041597698
*cite journal | author=Dahiya A, Wong S, Gonzalo S, "et al." |title=Linking the Rb and polycomb pathways. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 557–69 |year= 2001 |pmid= 11583618 |doi=
*cite journal | author=Ogawa H, Ishiguro K, Gaubatz S, "et al." |title=A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. |journal=Science |volume=296 |issue= 5570 |pages= 1132–6 |year= 2002 |pmid= 12004135 |doi= 10.1126/science.1069861
*cite journal | author=Akasaka T, Takahashi N, Suzuki M, "et al." |title=MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. |journal=Genes Cells |volume=7 |issue= 8 |pages= 835–50 |year= 2003 |pmid= 12167161 |doi=
*cite journal | author=Levine SS, Weiss A, Erdjument-Bromage H, "et al." |title=The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6070–8 |year= 2002 |pmid= 12167701 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Gil J, Bernard D, Martínez D, Beach D |title=Polycomb CBX7 has a unifying role in cellular lifespan. |journal=Nat. Cell Biol. |volume=6 |issue= 1 |pages= 67–72 |year= 2004 |pmid= 14647293 |doi= 10.1038/ncb1077
*cite journal | author=Obuse C, Yang H, Nozaki N, "et al." |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=
*cite journal | author=Wang H, Wang L, Erdjument-Bromage H, "et al." |title=Role of histone H2A ubiquitination in Polycomb silencing. |journal=Nature |volume=431 |issue= 7010 |pages= 873–8 |year= 2004 |pmid= 15386022 |doi= 10.1038/nature02985
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Qin H, Du D, Zhu Y, "et al." |title=The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2. |journal=FEBS Lett. |volume=579 |issue= 5 |pages= 1220–6 |year= 2005 |pmid= 15710417 |doi= 10.1016/j.febslet.2005.01.022
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links


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