IL13RA2

Interleukin 13 receptor, alpha 2, also known as IL13RA2 and CD213A2 (cluster of differentiation 213A2), is a human gene.cite web | title = Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.cite web | title = Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598| accessdate = ]

ee also

* Interleukin-13 receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Caput D, Laurent P, Kaghad M, "et al." |title=Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16921–6 |year= 1996 |pmid= 8663118 |doi=
*cite journal | author=Zhang JG, Hilton DJ, Willson TA, "et al." |title=Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9474–80 |year= 1997 |pmid= 9083087 |doi=
*cite journal | author=Gauchat JF, Schlagenhauf E, Feng NP, "et al." |title=A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. |journal=Eur. J. Immunol. |volume=27 |issue= 4 |pages= 971–8 |year= 1997 |pmid= 9130652 |doi=
*cite journal | author=Guo J, Apiou F, Mellerin MP, "et al." |title=Chromosome mapping and expression of the human interleukin-13 receptor. |journal=Genomics |volume=42 |issue= 1 |pages= 141–5 |year= 1997 |pmid= 9177784 |doi= 10.1006/geno.1997.4628
*cite journal | author=Donaldson DD, Whitters MJ, Fitz LJ, "et al." |title=The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. |journal=J. Immunol. |volume=161 |issue= 5 |pages= 2317–24 |year= 1998 |pmid= 9725226 |doi=
*cite journal | author=Osawa M, Miyoshi S, Copeland NG, "et al." |title=Characterization of the mouse interleukin-13 receptor alpha1 gene. |journal=Immunogenetics |volume=51 |issue= 11 |pages= 974–81 |year= 2000 |pmid= 11003391 |doi=
*cite journal | author=Kawakami K, Takeshita F, Puri RK |title=Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25114–20 |year= 2001 |pmid= 11352909 |doi= 10.1074/jbc.M100936200
*cite journal | author=Daines MO, Hershey GK |title=A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10387–93 |year= 2002 |pmid= 11786536 |doi= 10.1074/jbc.M108109200
*cite journal | author=Okano F, Storkus WJ, Chambers WH, "et al." |title=Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain. |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2851–5 |year= 2002 |pmid= 12231526 |doi=
*cite journal | author=Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, "et al." |title=Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein. |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1114–20 |year= 2003 |pmid= 12445201 |doi= 10.1046/j.1523-1747.2002.19509.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=David M, Bertoglio J, Pierre J |title=TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression. |journal=Ann. N. Y. Acad. Sci. |volume=973 |issue= |pages= 207–9 |year= 2003 |pmid= 12485861 |doi=
*cite journal | author=Wu AH, Low WC |title=Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter. |journal=Neuro-oncology |volume=5 |issue= 3 |pages= 179–87 |year= 2003 |pmid= 12816724 |doi= 10.1215/S1152-8517-02-00051-0
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Arima K, Sato K, Tanaka G, "et al." |title=Characterization of the interaction between interleukin-13 and interleukin-13 receptors. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24915–22 |year= 2005 |pmid= 15870068 |doi= 10.1074/jbc.M502571200
*cite journal | author=Fichtner-Feigl S, Strober W, Kawakami K, "et al." |title=IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. |journal=Nat. Med. |volume=12 |issue= 1 |pages= 99–106 |year= 2006 |pmid= 16327802 |doi= 10.1038/nm1332
*cite journal | author=Daines MO, Tabata Y, Walker BA, "et al." |title=Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling. |journal=J. Immunol. |volume=176 |issue= 12 |pages= 7495–501 |year= 2006 |pmid= 16751396 |doi=
*cite journal | author=Kioi M, Kawakami M, Shimamura T, "et al." |title=Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. |journal=Cancer |volume=107 |issue= 6 |pages= 1407–18 |year= 2006 |pmid= 16902988 |doi= 10.1002/cncr.22134
*cite journal | author=Granel B, Allanore Y, Chevillard C, "et al." |title=IL13RA2 gene polymorphisms are associated with systemic sclerosis. |journal=J. Rheumatol. |volume=33 |issue= 10 |pages= 2015–9 |year= 2007 |pmid= 16981293 |doi=

External links

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