Transcription elongation regulator 1

Transcription elongation regulator 1

Transcription elongation regulator 1, also known as TCERG1, is a human gene.cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url =| accessdate = ]

section_title =
summary_text = This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Suñé C, Hayashi T, Liu Y, "et al." |title=CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6029–39 |year= 1997 |pmid= 9315662 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Suñé C, Garcia-Blanco MA |title=Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4719–28 |year= 1999 |pmid= 10373521 |doi=
*cite journal | author=Carty SM, Goldstrohm AC, Suñé C, "et al." |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9015–20 |year= 2000 |pmid= 10908677 |doi= 10.1073/pnas.160266597
*cite journal | author=Bohne J, Cole SE, Suñe C, "et al." |title=Expression analysis and mapping of the mouse and human transcriptional regulator CA150. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 930–3 |year= 2000 |pmid= 11003711 |doi=
*cite journal | author=Holbert S, Denghien I, Kiechle T, "et al." |title=The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1811–6 |year= 2001 |pmid= 11172033 |doi= 10.1073/pnas.041566798
*cite journal | author=Goldstrohm AC, Albrecht TR, Suñé C, "et al." |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7617–28 |year= 2001 |pmid= 11604498 |doi= 10.1128/MCB.21.22.7617-7628.2001
*cite journal | author=Zhou Z, Licklider LJ, Gygi SP, Reed R |title=Comprehensive proteomic analysis of the human spliceosome. |journal=Nature |volume=419 |issue= 6903 |pages= 182–5 |year= 2002 |pmid= 12226669 |doi= 10.1038/nature01031
*cite journal | author=Carty SM, Greenleaf AL |title=Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. |journal=Mol. Cell Proteomics |volume=1 |issue= 8 |pages= 598–610 |year= 2003 |pmid= 12376575 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chattopadhyay B, Ghosh S, Gangopadhyay PK, "et al." |title=Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India. |journal=Neurosci. Lett. |volume=345 |issue= 2 |pages= 93–6 |year= 2003 |pmid= 12821179 |doi=
*cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, "et al." |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=
*cite journal | author=Palancade B, Marshall NF, Tremeau-Bravard A, "et al." |title=Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins. |journal=J. Mol. Biol. |volume=335 |issue= 2 |pages= 415–24 |year= 2004 |pmid= 14672652 |doi=
*cite journal | author=Nagel JE, Smith RJ, Shaw L, "et al." |title=Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10. |journal=BMC Immunol. |volume=5 |issue= |pages= 17 |year= 2005 |pmid= 15296517 |doi= 10.1186/1471-2172-5-17
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004
*cite journal | author=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274–85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=McFie PJ, Wang GL, Timchenko NA, "et al." |title=Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha. |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 18069–80 |year= 2006 |pmid= 16644732 |doi= 10.1074/jbc.M512734200

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