SMC3 (gene)

SMC3 (gene)

Structural maintenance of chromosomes 3, also known as SMC3, is a human gene.cite web | title = Entrez Gene: SMC3 structural maintenance of chromosomes 3| url =| accessdate = ]

section_title =
summary_text = This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.cite web | title = Entrez Gene: SMC3 structural maintenance of chromosomes 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Wu RR, Couchman JR |title=cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs. |journal=J. Cell Biol. |volume=136 |issue= 2 |pages= 433–44 |year= 1997 |pmid= 9015313 |doi=
*cite journal | author=Shimizu K, Shirataki H, Honda T, "et al." |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6591–4 |year= 1998 |pmid= 9506951 |doi=
*cite journal | author=Gupta K, Anand G, Yin X, "et al." |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |journal=Oncogene |volume=16 |issue= 9 |pages= 1149–59 |year= 1998 |pmid= 9528857 |doi= 10.1038/sj.onc.1201634
*cite journal | author=Schmiesing JA, Ball AR, Gregson HC, "et al." |title=Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 12906–11 |year= 1998 |pmid= 9789013 |doi=
*cite journal | author=Ghiselli G, Iozzo RV |title=Overexpression of bamacan/SMC3 causes transformation. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20235–8 |year= 2000 |pmid= 10801778 |doi= 10.1074/jbc.C000213200
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Sumara I, Vorlaufer E, Gieffers C, "et al." |title=Characterization of vertebrate cohesin complexes and their regulation in prophase. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 749–62 |year= 2000 |pmid= 11076961 |doi=
*cite journal | author=Revenkova E, Eijpe M, Heyting C, "et al." |title=Novel meiosis-specific isoform of mammalian SMC1. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6984–98 |year= 2001 |pmid= 11564881 |doi= 10.1128/MCB.21.20.6984-6998.2001
*cite journal | author=Gregson HC, Schmiesing JA, Kim JS, "et al." |title=A potential role for human cohesin in mitotic spindle aster assembly. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47575–82 |year= 2002 |pmid= 11590136 |doi= 10.1074/jbc.M103364200
*cite journal | author=Kim ST, Xu B, Kastan MB |title=Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. |journal=Genes Dev. |volume=16 |issue= 5 |pages= 560–70 |year= 2002 |pmid= 11877376 |doi= 10.1101/gad.970602
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=James RD, Schmiesing JA, Peters AH, "et al." |title=Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice. |journal=Chromosome Res. |volume=10 |issue= 7 |pages= 549–60 |year= 2003 |pmid= 12498344 |doi=
*cite journal | author=Ghiselli G, Coffee N, Munnery CE, "et al." |title=The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20259–67 |year= 2003 |pmid= 12651860 |doi= 10.1074/jbc.M209511200
*cite journal | author=Lee J, Iwai T, Yokota T, Yamashita M |title=Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 13 |pages= 2781–90 |year= 2004 |pmid= 12759374 |doi= 10.1242/jcs.00495
*cite journal | author=Prieto I, Tease C, Pezzi N, "et al." |title=Cohesin component dynamics during meiotic prophase I in mammalian oocytes. |journal=Chromosome Res. |volume=12 |issue= 3 |pages= 197–213 |year= 2004 |pmid= 15125634 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Patel CA, Ghiselli G |title=Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 3 |year= 2006 |pmid= 15656913 |doi= 10.1186/1471-2121-6-3
*cite journal | author=Rankin S, Ayad NG, Kirschner MW |title=Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. |journal=Mol. Cell |volume=18 |issue= 2 |pages= 185–200 |year= 2005 |pmid= 15837422 |doi= 10.1016/j.molcel.2005.03.017
*cite journal | author=Khanna H, Hurd TW, Lillo C, "et al." |title=RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. |journal=J. Biol. Chem. |volume=280 |issue= 39 |pages= 33580–7 |year= 2005 |pmid= 16043481 |doi= 10.1074/jbc.M505827200

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