GRIK1

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a human gene.cite web | title = Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2897| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as ligand-gate ionic channels. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Two alternatively spliced transcript variants that encode different isoforms have been described. Exons of this gene are interspersed with exons from the C21orf41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.cite web | title = Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2897| accessdate = ]

ee also

* Kainate receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nutt SL, Kamboj RK |title=RNA editing of human kainate receptor subunits. |journal=Neuroreport |volume=5 |issue= 18 |pages= 2625–9 |year= 1995 |pmid= 7696618 |doi=
*cite journal | author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11679–82 |year= 1994 |pmid= 8163463 |doi=
*cite journal | author=Gregor P, O'Hara BF, Yang X, Uhl GR |title=Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. |journal=Neuroreport |volume=4 |issue= 12 |pages= 1343–6 |year= 1994 |pmid= 8260617 |doi=
*cite journal | author=Eubanks JH, Puranam RS, Kleckner NW, "et al." |title=The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 1 |pages= 178–82 |year= 1993 |pmid= 8419920 |doi=
*cite journal | author=Potier MC, Dutriaux A, Lambolez B, "et al." |title=Assignment of the human glutamate receptor gene GLUR5 to 21q22 by screening a chromosome 21 YAC library. |journal=Genomics |volume=15 |issue= 3 |pages= 696–7 |year= 1993 |pmid= 8468067 |doi= 10.1006/geno.1993.1131
*cite journal | author=Korczak B, Nutt SL, Fletcher EJ, "et al." |title=cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. |journal=Recept. Channels |volume=3 |issue= 1 |pages= 41–9 |year= 1996 |pmid= 8589992 |doi=
*cite journal | author=Brakeman PR, Lanahan AA, O'Brien R, "et al." |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 284–8 |year= 1997 |pmid= 9069287 |doi= 10.1038/386284a0
*cite journal | author=Sander T, Hildmann T, Kretz R, "et al." |title=Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. |journal=Am. J. Med. Genet. |volume=74 |issue= 4 |pages= 416–21 |year= 1997 |pmid= 9259378 |doi=
*cite journal | author=Clarke VR, Ballyk BA, Hoo KH, "et al." |title=A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. |journal=Nature |volume=389 |issue= 6651 |pages= 599–603 |year= 1997 |pmid= 9335499 |doi= 10.1038/39315
*cite journal | author=Xiao B, Tu JC, Petralia RS, "et al." |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue= 4 |pages= 707–16 |year= 1998 |pmid= 9808458 |doi=
*cite journal | author=Montague AA, Greer CA |title=Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. |journal=J. Comp. Neurol. |volume=405 |issue= 2 |pages= 233–46 |year= 1999 |pmid= 10023812 |doi=
*cite journal | author=Bortolotto ZA, Clarke VR, Delany CM, "et al." |title=Kainate receptors are involved in synaptic plasticity. |journal=Nature |volume=402 |issue= 6759 |pages= 297–301 |year= 1999 |pmid= 10580501 |doi= 10.1038/46290
*cite journal | author=Barbon A, Barlati S |title=Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 236–9 |year= 2000 |pmid= 10828597 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Ango F, Prézeau L, Muller T, "et al." |title=Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. |journal=Nature |volume=411 |issue= 6840 |pages= 962–5 |year= 2001 |pmid= 11418862 |doi= 10.1038/35082096
*cite journal | author=Shibata H, Joo A, Fujii Y, "et al." |title=Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. |journal=Psychiatr. Genet. |volume=11 |issue= 3 |pages= 139–44 |year= 2002 |pmid= 11702055 |doi=
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200
*cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184–8 |year= 2002 |pmid= 11943148 |doi=
*cite journal | author=Hirbec H, Francis JC, Lauri SE, "et al." |title=Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. |journal=Neuron |volume=37 |issue= 4 |pages= 625–38 |year= 2003 |pmid= 12597860 |doi=
*cite journal | author=Ren Z, Riley NJ, Needleman LA, "et al." |title=Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52700–9 |year= 2004 |pmid= 14527949 |doi= 10.1074/jbc.M309585200

External links

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