DSC1


DSC1
Desmocollin 1
Identifiers
Symbols DSC1; CDHF1; DG2/DG3
External IDs OMIM125643 MGI109173 HomoloGene22761 GeneCards: DSC1 Gene
RNA expression pattern
PBB GE DSC1 207324 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1823 13505
Ensembl ENSG00000134765 ENSMUSG00000044322
UniProt Q08554 Q2VPA9
RefSeq (mRNA) NM_004948.3 NM_013504.4
RefSeq (protein) NP_004939.1 NP_038532.3
Location (UCSC) Chr 18:
28.71 – 28.74 Mb
Chr 18:
20.24 – 20.27 Mb
PubMed search [1] [2]

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[1][2]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[2]

Interactions

DSC1 has been shown to interact with Desmoglein 2.[3]

References

Further reading



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