Desmocollin 1
Symbols DSC1; CDHF1; DG2/DG3
External IDs OMIM125643 MGI109173 HomoloGene22761 GeneCards: DSC1 Gene
RNA expression pattern
PBB GE DSC1 207324 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1823 13505
Ensembl ENSG00000134765 ENSMUSG00000044322
UniProt Q08554 Q2VPA9
RefSeq (mRNA) NM_004948.3 NM_013504.4
RefSeq (protein) NP_004939.1 NP_038532.3
Location (UCSC) Chr 18:
28.71 – 28.74 Mb
Chr 18:
20.24 – 20.27 Mb
PubMed search [1] [2]

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[1][2]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[2]


DSC1 has been shown to interact with Desmoglein 2.[3]


Further reading

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • DSC3 — Desmocollin 3 Identifiers Symbols DSC3; CDHF3; DSC; DSC1; DSC2; DSC4; HT CP External IDs …   Wikipedia

  • Desmoglein 2 — Identifiers Symbols DSG2; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC; MGC117034; MGC117036; MGC117037 External IDs …   Wikipedia

  • Deer hunting — Theodore Roosevelt in 1885 with his highly decorated deer skin hunting suit, and Tiffany carved hunting knife and rifle. See also: Deer stalking Main article: Hunting Deer hunting is survival hunting or sport hunting, harvesting …   Wikipedia

  • Desmocollin — is a type of cadherin.[1] Specifically, it can refer to one of the following human genes : DSC1 DSC2 DSC3 References ^ MeSH Desmocollins …   Wikipedia

  • Distinguished Service Cross (United States Army) — Infobox Military Award name=Distinguished Service Cross caption=Current Distinguished Service Cross Medal and Ribbon Set awarded by=United States Army type=Medal eligibility=The Distinguished Service Cross is awarded to a person who, while… …   Wikipedia

  • Cell adhesion — Cellular adhesion is the binding of a cell to a surface, extracellular matrix or another cell using cell adhesion molecules such as selectins, integrins, and cadherins. Correct cellular adhesion is essential in maintaining multicellular structure …   Wikipedia

  • Cadherin — Cadherins are a class of type 1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.The cadherin… …   Wikipedia

  • Cell adhesion molecule — Cell Adhesion Molecules (CAMs) are proteins located on the cell surface[1] involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors …   Wikipedia

  • Neural cell adhesion molecule — 1 PDB rendering based on 1epf …   Wikipedia

  • CD31 — Platelet/endothelial cell adhesion molecule Identifiers Symbols PECAM1; CD31; FLJ34100; FLJ58394; PECAM 1 External IDs …   Wikipedia