CDKN2D


CDKN2D

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), also known as CDKN2D, is a human gene.cite web | title = Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1032| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.cite web | title = Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1032| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hirai H, Roussel MF, Kato JY, "et al." |title=Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2672–81 |year= 1995 |pmid= 7739547 |doi=
*cite journal | author=Chan FK, Zhang J, Cheng L, "et al." |title=Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2682–8 |year= 1995 |pmid= 7739548 |doi=
*cite journal | author=Okuda T, Hirai H, Valentine VA, "et al." |title=Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. |journal=Genomics |volume=29 |issue= 3 |pages= 623–30 |year= 1996 |pmid= 8575754 |doi= 10.1006/geno.1995.9957
*cite journal | author=Guan KL, Jenkins CW, Li Y, "et al." |title=Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. |journal=Mol. Biol. Cell |volume=7 |issue= 1 |pages= 57–70 |year= 1996 |pmid= 8741839 |doi=
*cite journal | author=Schwaller J, Pabst T, Koeffler HP, "et al." |title=Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells. |journal=Leukemia |volume=11 |issue= 1 |pages= 54–63 |year= 1997 |pmid= 9001419 |doi=
*cite journal | author=Russo AA, Tong L, Lee JO, "et al." |title=Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. |journal=Nature |volume=395 |issue= 6699 |pages= 237–43 |year= 1998 |pmid= 9751050 |doi= 10.1038/26155
*cite journal | author=Brotherton DH, Dhanaraj V, Wick S, "et al." |title=Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. |journal=Nature |volume=395 |issue= 6699 |pages= 244–50 |year= 1998 |pmid= 9751051 |doi= 10.1038/26164
*cite journal | author=Baumgartner R, Fernandez-Catalan C, Winoto A, "et al." |title=Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. |journal=Structure |volume=6 |issue= 10 |pages= 1279–90 |year= 1998 |pmid= 9782052 |doi=
*cite journal | author=Schreiber M, Muller WJ, Singh G, Graham FL |title=Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |journal=Oncogene |volume=18 |issue= 9 |pages= 1663–76 |year= 1999 |pmid= 10208428 |doi= 10.1038/sj.onc.1202466
*cite journal | author=Newton Bishop JA, Harland M, Bennett DC, "et al." |title=Mutation testing in melanoma families: INK4A, CDK4 and INK4D. |journal=Br. J. Cancer |volume=80 |issue= 1-2 |pages= 295–300 |year= 1999 |pmid= 10390011 |doi= 10.1038/sj.bjc.6690354
*cite journal | author=Zindy F, Cunningham JJ, Sherr CJ, "et al." |title=Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13462–7 |year= 1999 |pmid= 10557343 |doi=
*cite journal | author=Thullberg M, Bartkova J, Khan S, "et al." |title=Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors. |journal=FEBS Lett. |volume=470 |issue= 2 |pages= 161–6 |year= 2000 |pmid= 10734227 |doi=
*cite journal | author=Bartkova J, Thullberg M, Rajpert-De Meyts E, "et al." |title=Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. |journal=Oncogene |volume=19 |issue= 36 |pages= 4146–50 |year= 2000 |pmid= 10962575 |doi= 10.1038/sj.onc.1203769
*cite journal | author=Fink JR, LeBien TW |title=Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors. |journal=Exp. Hematol. |volume=29 |issue= 4 |pages= 490–8 |year= 2001 |pmid= 11301189 |doi=
*cite journal | author=Zeeb M, Rösner H, Zeslawski W, "et al." |title=Protein folding and stability of human CDK inhibitor p19(INK4d). |journal=J. Mol. Biol. |volume=315 |issue= 3 |pages= 447–57 |year= 2002 |pmid= 11786024 |doi= 10.1006/jmbi.2001.5242
*cite journal | author=Matsuzaki Y, Miyazawa K, Yokota T, "et al." |title=Molecular cloning and characterization of the human p19(INK4d) gene promoter. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 272–6 |year= 2002 |pmid= 12062451 |doi=
*cite journal | author=Arcellana-Panlilio MY, Egeler RM, Ujack E, "et al." |title=Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. |journal=Genes Chromosomes Cancer |volume=35 |issue= 2 |pages= 176–81 |year= 2002 |pmid= 12203782 |doi= 10.1002/gcc.10108
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Komata T, Kanzawa T, Takeuchi H, "et al." |title=Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. |journal=Br. J. Cancer |volume=88 |issue= 8 |pages= 1277–80 |year= 2004 |pmid= 12698196 |doi= 10.1038/sj.bjc.6600862

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  • Cyclin-dependent kinase inhibitor protein — Cyclin dependent kinase inhibitor Structure of the p27Kip1 cyclin dependent kinase inhibitor bound to the cyclin A Cdk2 complex.[1] Identifiers …   Wikipedia


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