LHX3

LIM homeobox 3, also known as LHX3, is a human gene.cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8022| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Two transcripts variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8022| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhadanov AB, Bertuzzi S, Taira M, "et al." |title=Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. |journal=Dev. Dyn. |volume=202 |issue= 4 |pages= 354–64 |year= 1995 |pmid= 7626792 |doi= 10.1002/aja.1002020405
*cite journal | author=Zhadanov AB, Copeland NG, Gilbert DJ, "et al." |title=Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3. |journal=Genomics |volume=27 |issue= 1 |pages= 27–32 |year= 1995 |pmid= 7665181 |doi= 10.1006/geno.1995.1004
*cite journal | author=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=
*cite journal | author=Bach I, Rodriguez-Esteban C, Carrière C, "et al." |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970
*cite journal | author=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159–67 |year= 2000 |pmid= 10593900 |doi=
*cite journal | author=Sloop KW, Meier BC, Bridwell JL, "et al." |title=Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2212–25 |year= 2000 |pmid= 10598593 |doi=
*cite journal | author=Sloop KW, Showalter AD, Von Kap-Herr C, "et al." |title=Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9. |journal=Gene |volume=245 |issue= 2 |pages= 237–43 |year= 2000 |pmid= 10717474 |doi=
*cite journal | author=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336–42 |year= 2000 |pmid= 10788441 |doi=
*cite journal | author=Parker GE, Sandoval RM, Feister HA, "et al." |title=The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23891–8 |year= 2000 |pmid= 10818088 |doi= 10.1074/jbc.M000377200
*cite journal | author=Netchine I, Sobrier ML, Krude H, "et al." |title=Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency. |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 182–6 |year= 2000 |pmid= 10835633 |doi= 10.1038/76041
*cite journal | author=Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ |title=Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 49–56 |year= 2000 |pmid= 10903894 |doi= 10.1006/bbrc.2000.3038
*cite journal | author=Sloop KW, Dwyer CJ, Rhodes SJ |title=An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36311–9 |year= 2001 |pmid= 11470784 |doi= 10.1074/jbc.M103888200
*cite journal | author=Ostendorff HP, Peirano RI, Peters MA, "et al." |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. |journal=Nature |volume=416 |issue= 6876 |pages= 99–103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. |journal=Development |volume=130 |issue= 9 |pages= 1915–25 |year= 2003 |pmid= 12642495 |doi=
*cite journal | author=Kim SS, Kim Y, Shin YL, "et al." |title=Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging. |journal=Horm. Res. |volume=60 |issue= 6 |pages= 277–83 |year= 2004 |pmid= 14646405 |doi= 10.1159/000074245
*cite journal | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207–9 |year= 2004 |pmid= 14714741 |doi=
*cite journal | author=West BE, Parker GE, Savage JJ, "et al." |title=Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor. |journal=Endocrinology |volume=145 |issue= 11 |pages= 4866–79 |year= 2004 |pmid= 15271874 |doi= 10.1210/en.2004-0598
*cite journal | author=Parker GE, West BE, Witzmann FA, Rhodes SJ |title=Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor. |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 67–80 |year= 2005 |pmid= 15517599 |doi= 10.1002/jcb.20287
*cite journal | author=Sobrier ML, Attié-Bitach T, Netchine I, "et al." |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development. |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279–84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003

External links

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