LIMK2

LIM domain kinase 2, also known as LIMK2, is a human gene.cite web | title = Entrez Gene: LIMK2 LIM domain kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3985| accessdate = ]

PBB_Summary
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summary_text = There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: LIMK2 LIM domain kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3985| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott RW, Olson MF |title=LIM kinases: function, regulation and association with human disease. |journal=J. Mol. Med. |volume=85 |issue= 6 |pages= 555–68 |year= 2007 |pmid= 17294230 |doi= 10.1007/s00109-007-0165-6
*cite journal | author=Okano I, Hiraoka J, Otera H, "et al." |title=Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31321–30 |year= 1996 |pmid= 8537403 |doi=
*cite journal | author=Osada H, Hasada K, Inazawa J, "et al." |title=Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 2 |pages= 582–9 |year= 1997 |pmid= 8954941 |doi= 10.1006/bbrc.1996.1847
*cite journal | author=Hiraoka J, Okano I, Higuchi O, "et al." |title=Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain. |journal=FEBS Lett. |volume=399 |issue= 1-2 |pages= 117–21 |year= 1997 |pmid= 8980133 |doi=
*cite journal | author=Yang N, Higuchi O, Ohashi K, "et al." |title=Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. |journal=Nature |volume=393 |issue= 6687 |pages= 809–12 |year= 1998 |pmid= 9655398 |doi= 10.1038/31735
*cite journal | author=Nomoto S, Tatematsu Y, Takahashi T, Osada H |title=Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression. |journal=Gene |volume=236 |issue= 2 |pages= 259–71 |year= 1999 |pmid= 10452946 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Sumi T, Matsumoto K, Takai Y, Nakamura T |title=Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. |journal=J. Cell Biol. |volume=147 |issue= 7 |pages= 1519–32 |year= 2000 |pmid= 10613909 |doi=
*cite journal | author=Sumi T, Matsumoto K, Nakamura T |title=Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 670–6 |year= 2001 |pmid= 11018042 |doi= 10.1074/jbc.M007074200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Amano T, Tanabe K, Eto T, "et al." |title=LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. |journal=Biochem. J. |volume=354 |issue= Pt 1 |pages= 149–59 |year= 2001 |pmid= 11171090 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Sumi T, Matsumoto K, Shibuya A, Nakamura T |title=Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23092–6 |year= 2001 |pmid= 11340065 |doi= 10.1074/jbc.C100196200
*cite journal | author=Toshima J, Toshima JY, Takeuchi K, "et al." |title=Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31449–58 |year= 2001 |pmid= 11418599 |doi= 10.1074/jbc.M102988200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Vardouli L, Moustakas A, Stournaras C |title=LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11448–57 |year= 2005 |pmid= 15647284 |doi= 10.1074/jbc.M402651200

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